| 1 |
34464807 | Comparison of recovery characteristics between AnAOB and AOB-AnAOB granular sludge after long-term storage. | 2022 Jan 1 |
1 |
| 2 |
34953855 | The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. | 2022 Feb |
5 |
| 3 |
35253073 | Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases. | 2022 Mar 7 |
1 |
| 4 |
32820034 | CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. | 2021 Jul |
2 |
| 5 |
33904374 | Identification of selective LdDHFR inhibitors using quantum chemical and molecular modeling approach. | 2021 Apr 27 |
1 |
| 6 |
34412467 | Targeted Mitochondrial Fluorescence Imaging-Guided Tumor Antimetabolic Therapy with the Imprinted Polymer Nanomedicine Capable of Specifically Recognizing Dihydrofolate Reductase. | 2021 Sep 1 |
2 |
| 7 |
34710812 | Computational algorithmic and molecular dynamics study of functional and structural impacts of non-synonymous single nucleotide polymorphisms in human DHFR gene. | 2021 Dec |
2 |
| 8 |
34825630 | 3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors. | 2021 Nov 26 |
2 |
| 9 |
34829516 | CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells. | 2021 Oct 20 |
2 |
| 10 |
32319147 | Significant association between DHFR promoter methylation and ischemic stroke in a Chinese hypertensive population. | 2020 Aug |
1 |
| 11 |
32498709 | Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study. | 2020 Jun 4 |
3 |
| 12 |
32752079 | In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics. | 2020 Jul 31 |
2 |
| 13 |
31058257 | NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. | 2019 Mar |
1 |
| 14 |
31401334 | Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer. | 2019 Nov |
1 |
| 15 |
31443485 | Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS). | 2019 Aug 22 |
1 |
| 16 |
31542479 | DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide. | 2019 Nov 15 |
2 |
| 17 |
31920364 | Evaluation of Hematological Parameters in the Genetic Prospective in Epileptic Patients of Khyber Pakhtunkhwa. | 2019 |
1 |
| 18 |
29321536 | Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. | 2018 Jan 10 |
1 |
| 19 |
29708443 | Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study. | 2018 Nov |
2 |
| 20 |
30120883 | Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India. | 2018 Aug 15 |
2 |
| 21 |
28188287 | A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. | 2017 Mar 24 |
1 |
| 22 |
28338744 | Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR. | 2017 Mar 1 |
3 |
| 23 |
28496133 | Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity. | 2017 May 11 |
4 |
| 24 |
28939533 | Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors. | 2017 Dec |
2 |
| 25 |
28939595 | Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants. | 2017 Nov |
4 |
| 26 |
26229988 | Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate. | 2016 Jan 21 |
2 |
| 27 |
26881719 | Repositioning of DHFR Inhibitors. | 2016 |
1 |
| 28 |
26929741 | Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation. | 2016 |
2 |
| 29 |
27013776 | Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression. | 2016 Mar |
1 |
| 30 |
27064332 | Assessment of Folic Acid Supplementation in Pregnant Women by Estimation of Serum Levels of Tetrahydrofolic Acid, Dihydrofolate Reductase, and Homocysteine. | 2016 |
1 |
| 31 |
27131640 | Excessive folic acid intake and relation to adverse health outcome. | 2016 Jul |
1 |
| 32 |
27189223 | Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. | 2016 May |
2 |
| 33 |
27213086 | Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption. | 2016 |
1 |
| 34 |
27919952 | Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer. | 2016 Dec |
1 |
| 35 |
27994750 | Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. | 2016 Dec 8 |
1 |
| 36 |
25315410 | A novel antibiotic-delivery system by using ovotransferrin as targeting molecule. | 2015 Jan 23 |
2 |
| 37 |
25441416 | Miniature multi-channel SPR instrument for methotrexate monitoring in clinical samples. | 2015 Feb 15 |
1 |
| 38 |
26022931 | New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans. | 2015 Aug |
1 |
| 39 |
26131691 | Methotrexate Is a JAK/STAT Pathway Inhibitor. | 2015 |
1 |
| 40 |
26144049 | The role of folate metabolism in orofacial development and clefting. | 2015 Sep 1 |
1 |
| 41 |
26269242 | The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake. | 2015 Oct |
3 |
| 42 |
26354538 | Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. | 2015 Nov |
4 |
| 43 |
26414244 | Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. | 2015 Nov 10 |
1 |
| 44 |
26875486 | Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report. | 2015 |
5 |
| 45 |
24705454 | Influence of the Debye length on the interaction of a small molecule-modified Au nanoparticle with a surface-bound bioreceptor. | 2014 May 18 |
3 |
| 46 |
24739308 | Origin of robustness in generating drug-resistant malaria parasites. | 2014 Jul |
1 |
| 47 |
27025730 | Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery. | 2014 Jan 21 |
3 |
| 48 |
23421317 | DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome. | 2013 Apr |
5 |
| 49 |
23552564 | Exploration of 2, 4-diaminopyrimidine and 2, 4-diamino-s-triazine derivatives as potential antifilarial agents. | 2013 Jul |
1 |
| 50 |
23707606 | Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. | 2013 Oct |
2 |