Folic Acid

dihydrofolate reductase ; Homo sapiens







150 Article(s)
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1 34464807 Comparison of recovery characteristics between AnAOB and AOB-AnAOB granular sludge after long-term storage. 2022 Jan 1 1
2 34953855 The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. 2022 Feb 5
3 35253073 Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases. 2022 Mar 7 1
4 32820034 CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. 2021 Jul 2
5 33904374 Identification of selective LdDHFR inhibitors using quantum chemical and molecular modeling approach. 2021 Apr 27 1
6 34412467 Targeted Mitochondrial Fluorescence Imaging-Guided Tumor Antimetabolic Therapy with the Imprinted Polymer Nanomedicine Capable of Specifically Recognizing Dihydrofolate Reductase. 2021 Sep 1 2
7 34710812 Computational algorithmic and molecular dynamics study of functional and structural impacts of non-synonymous single nucleotide polymorphisms in human DHFR gene. 2021 Dec 2
8 34825630 3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors. 2021 Nov 26 2
9 34829516 CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells. 2021 Oct 20 2
10 32319147 Significant association between DHFR promoter methylation and ischemic stroke in a Chinese hypertensive population. 2020 Aug 1
11 32498709 Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study. 2020 Jun 4 3
12 32752079 In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics. 2020 Jul 31 2
13 31058257 NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. 2019 Mar 1
14 31401334 Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer. 2019 Nov 1
15 31443485 Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS). 2019 Aug 22 1
16 31542479 DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide. 2019 Nov 15 2
17 31920364 Evaluation of Hematological Parameters in the Genetic Prospective in Epileptic Patients of Khyber Pakhtunkhwa. 2019 1
18 29321536 Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. 2018 Jan 10 1
19 29708443 Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study. 2018 Nov 2
20 30120883 Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India. 2018 Aug 15 2
21 28188287 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. 2017 Mar 24 1
22 28338744 Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR. 2017 Mar 1 3
23 28496133 Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity. 2017 May 11 4
24 28939533 Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors. 2017 Dec 2
25 28939595 Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants. 2017 Nov 4
26 26229988 Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate. 2016 Jan 21 2
27 26881719 Repositioning of DHFR Inhibitors. 2016 1
28 26929741 Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation. 2016 2
29 27013776 Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression. 2016 Mar 1
30 27064332 Assessment of Folic Acid Supplementation in Pregnant Women by Estimation of Serum Levels of Tetrahydrofolic Acid, Dihydrofolate Reductase, and Homocysteine. 2016 1
31 27131640 Excessive folic acid intake and relation to adverse health outcome. 2016 Jul 1
32 27189223 Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. 2016 May 2
33 27213086 Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption. 2016 1
34 27919952 Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer. 2016 Dec 1
35 27994750 Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. 2016 Dec 8 1
36 25315410 A novel antibiotic-delivery system by using ovotransferrin as targeting molecule. 2015 Jan 23 2
37 25441416 Miniature multi-channel SPR instrument for methotrexate monitoring in clinical samples. 2015 Feb 15 1
38 26022931 New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans. 2015 Aug 1
39 26131691 Methotrexate Is a JAK/STAT Pathway Inhibitor. 2015 1
40 26144049 The role of folate metabolism in orofacial development and clefting. 2015 Sep 1 1
41 26269242 The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake. 2015 Oct 3
42 26354538 Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. 2015 Nov 4
43 26414244 Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. 2015 Nov 10 1
44 26875486 Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report. 2015 5
45 24705454 Influence of the Debye length on the interaction of a small molecule-modified Au nanoparticle with a surface-bound bioreceptor. 2014 May 18 3
46 24739308 Origin of robustness in generating drug-resistant malaria parasites. 2014 Jul 1
47 27025730 Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery. 2014 Jan 21 3
48 23421317 DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome. 2013 Apr 5
49 23552564 Exploration of 2, 4-diaminopyrimidine and 2, 4-diamino-s-triazine derivatives as potential antifilarial agents. 2013 Jul 1
50 23707606 Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. 2013 Oct 2