10 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 24754871 | Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes. | 2014 Aug 4 | 1 |
2 | 19839929 | The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action. | 2010 Jan | 2 |
3 | 9762351 | Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). | 1998 | 1 |
4 | 8820948 | Methotrexate: an effective agent for treating cancer and building careers. The polyglutamate era. | 1996 Jan | 1 |
5 | 10387997 | Methotrexate: An Effective Agent for Treating Cancer and Building Careers. The Polyglutamate Era. | 1996 | 1 |
6 | 2448654 | Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. | 1987 | 2 |
7 | 3431589 | Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase. | 1987 | 1 |
8 | 2414022 | Insulin effects on methotrexate polyglutamate synthesis and enzyme binding in cultured human breast cancer cells. | 1985 | 4 |
9 | 6193143 | Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. | 1983 Sep | 2 |
10 | 6838652 | Interaction of methotrexate metabolites with beef liver dihydrofolate reductase-I. Binary complex study. | 1983 Mar 15 | 2 |