Polyglutamic Acid

dihydrofolate reductase ; Homo sapiens







10 Article(s)
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Title
Pub. Year
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1 24754871 Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes. 2014 Aug 4 1
2 19839929 The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action. 2010 Jan 2
3 9762351 Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). 1998 1
4 8820948 Methotrexate: an effective agent for treating cancer and building careers. The polyglutamate era. 1996 Jan 1
5 10387997 Methotrexate: An Effective Agent for Treating Cancer and Building Careers. The Polyglutamate Era. 1996 1
6 2448654 Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. 1987 2
7 3431589 Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase. 1987 1
8 2414022 Insulin effects on methotrexate polyglutamate synthesis and enzyme binding in cultured human breast cancer cells. 1985 4
9 6193143 Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. 1983 Sep 2
10 6838652 Interaction of methotrexate metabolites with beef liver dihydrofolate reductase-I. Binary complex study. 1983 Mar 15 2