Dacarbazine

O-6-methylguanine-DNA methyltransferase ; Homo sapiens







23 Article(s)
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1 33816296 LncRNA POU3F3 Contributes to Dacarbazine Resistance of Human Melanoma Through the MiR-650/MGMT Axis. 2021 2
2 27997874 Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients. 2017 Jan 1
3 26916096 Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer. 2016 Jun 2
4 25400033 MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma. 2015 Jun 15 6
5 25584486 O6-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents. 2015 Feb 3 1
6 26113646 Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. 2015 Sep 4
7 24284332 Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells. 2014 Jan 4
8 25516857 Role of MGMT as biomarker in colorectal cancer. 2014 Dec 16 1
9 23422094 Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. 2013 Apr 15 4
10 21811257 Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours. 2011 Sep 6 2
11 20541396 MGMT expression levels predict disease stabilisation, progression-free and overall survival in patients with advanced melanomas treated with DTIC. 2010 Jul 6
12 19741564 Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians. 2009 Oct 5
13 17881774 Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis. 2007 Dec 3
14 15870882 Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. 2005 Jun 5
15 16278661 O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. 2005 Nov 14 2
16 15010317 Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations. 2004 Apr 1 2
17 14562026 O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma. 2003 Oct 20 5
18 12168066 Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy. 2002 Sep-Oct 1
19 12170182 Analysis of O(6)-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy. 2002 Aug 6
20 10751609 Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase. 2000 Feb 14 1
21 9071912 Immunohistochemical examination of the expression of O6-methylguanine-DNA methyltransferase in human melanoma metastases. 1997 Jan 1
22 8645346 Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents. 1996 May 3 5
23 9038616 Analysis of O6-methylguanine-DNA methyltransferase mRNA in fine needle biopsies from human melanoma metastases by reverse transcription and polymerase chain reaction. 1996 Dec 2