| 1 |
31924695 | Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6. | 2020 Mar |
5 |
| 2 |
33551819 | Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR). | 2020 |
1 |
| 3 |
30592088 | The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization. | 2019 May |
1 |
| 4 |
31270214 | Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing. | 2019 Sep |
1 |
| 5 |
31436536 | Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. | 2019 Sep |
1 |
| 6 |
29357810 | Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells. | 2018 |
1 |
| 7 |
25336106 | HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics. | 2015 |
1 |
| 8 |
25409894 | Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. | 2015 Feb |
7 |
| 9 |
25600204 | Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays. | 2015 |
1 |
| 10 |
24252946 | Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling. | 2014 Feb |
1 |
| 11 |
24553381 | Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. | 2014 May |
1 |
| 12 |
23858795 | [Species difference in the metabolism of 2, 2', 3, 4', 5, 5'-hexachlorobiphenyl (CB146) by animal and human liver microsomes]. | 2013 Apr |
1 |
| 13 |
21111054 | Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. | 2011 May-Jun |
1 |
| 14 |
19833192 | Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes. | 2010 Mar |
1 |
| 15 |
20019244 | Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. | 2010 Mar |
2 |
| 16 |
20307138 | Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. | 2010 Jun |
1 |
| 17 |
20509749 | Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues. | 2010 Aug |
1 |
| 18 |
20516253 | Histone deacetylase inhibitors induce cytochrome P450 2B by activating nuclear receptor constitutive androstane receptor. | 2010 Sep |
1 |
| 19 |
20583967 | A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin. | 2010 Dec |
1 |
| 20 |
18983865 | Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. | 2009 Jan 15 |
1 |
| 21 |
18022748 | Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. | 2008 Jan 14 |
1 |
| 22 |
18094037 | Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. | 2008 Mar |
1 |
| 23 |
18332078 | Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. | 2008 Jun |
1 |
| 24 |
18474683 | The Nrf2 activator oltipraz also activates the constitutive androstane receptor. | 2008 Aug |
2 |
| 25 |
17638512 | Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance. | 2007 Jul |
2 |
| 26 |
17904175 | DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. | 2007 Dec 15 |
2 |
| 27 |
17992728 | Roles of human CYP2A6 and rat CYP2B1 in the oxidation of (+)-fenchol by liver microsomes. | 2007 Sep |
1 |
| 28 |
16623664 | Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. | 2006 Aug 15 |
2 |
| 29 |
16988011 | Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. | 2006 Dec |
2 |
| 30 |
15563456 | Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. | 2005 Feb 4 |
4 |
| 31 |
15572372 | AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. | 2005 Feb 11 |
3 |
| 32 |
15703377 | Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins. | 2005 May |
1 |
| 33 |
15802384 | Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. | 2005 Jul |
2 |
| 34 |
16012075 | Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes. | 2005 May |
1 |
| 35 |
16135659 | Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction. | 2005 Dec |
1 |
| 36 |
20021072 | Impact of genetic polymorphism in relation to other factors on expression and function of human drug-metabolizing p450s. | 2005 |
1 |
| 37 |
14977870 | Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. | 2004 Mar |
1 |
| 38 |
14978227 | Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver. | 2004 Mar |
2 |
| 39 |
15123723 | Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. | 2004 Jul 9 |
1 |
| 40 |
15382119 | Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. | 2004 Oct |
1 |
| 41 |
12511605 | Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. | 2003 Jan |
1 |
| 42 |
12695351 | Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. | 2003 May |
2 |
| 43 |
12739762 | Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices. | 2003 Apr |
2 |
| 44 |
12815172 | Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. | 2003 Jul |
1 |
| 45 |
12870655 | Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid. | 2003 Jun |
1 |
| 46 |
14683479 | Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. | 2003 Dec |
2 |
| 47 |
11854139 | (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. | 2002 Mar |
1 |
| 48 |
11181490 | Induction of CYP2C genes in human hepatocytes in primary culture. | 2001 Mar |
2 |
| 49 |
11231298 | Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. | 2001 Mar |
1 |
| 50 |
11257517 | Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies. | 2001 Mar 9 |
1 |