Lactic Acid

pyruvate dehydrogenase phosphatase catalytic subunit 1 ; Homo sapiens







38 Article(s)
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1 33675030 Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance. 2022 Mar 1
2 31828927 miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1. 2020 Mar 1
3 32433492 Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. 2020 May 20 1
4 32998265 Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas. 2020 Sep 28 5
5 29444744 Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma. 2019 Mar 29 1
6 30923124 Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. 2019 May 10 3
7 31792175 Repurposing dichloroacetate for the treatment of women with endometriosis. 2019 Dec 17 2
8 29615918 Skeletal Muscle Pyruvate Dehydrogenase Phosphorylation and Lactate Accumulation During Sprint Exercise in Normoxia and Severe Acute Hypoxia: Effects of Antioxidants. 2018 1
9 28536031 Lactate induces osteoblast differentiation by stabilization of HIF1α. 2017 Sep 5 1
10 28846077 Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts. 2017 Nov 1
11 27144334 Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. 2016 Jun 7 1
12 27179453 Metabolic reprogramming by the pyruvate dehydrogenase kinase-lactic acid axis: Linking metabolism and diverse neuropathophysiologies. 2016 Sep 4
13 27221120 Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. 2016 Jul 1 2
14 25046652 Using [1-(13) C]lactic acid for hyperpolarized (13) C MR cardiac studies. 2015 Jun 1
15 24452394 High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. 2014 Mar 1
16 22508045 Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy? 2012 2
17 21346867 Development of a less toxic dichloroacetate analogue by docking and descriptor analysis. 2010 Jul 6 1
18 17384007 Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. 2007 May 3
19 17521432 Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase. 2007 May 23 1
20 16469933 Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance. 2006 Jun 1
21 10649979 Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase. 2000 Jan 27 2
22 10710508 Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia. 2000 Mar 1
23 10776894 An enzymatic approach to lactate production in human skeletal muscle during exercise. 2000 Apr 1
24 10826498 Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. 2000 Apr 1
25 11001755 Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. 2000 Oct 2
26 10486093 Cerebral palsy and pyruvate dehydrogenase deficiency: identification of two new mutations in the E1alpha gene. 1999 Oct 1
27 10567017 Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. 1999 Nov 2
28 9546635 Regulation of carbohydrate and fatty acid utilization by L-carnitine during cardiac development and hypoxia. 1998 Mar 1
29 9555066 Effect of hyperglycemia on pyruvate dehydrogenase activity and energy metabolites during ischemia and reperfusion in gerbil brain. 1998 Mar 30 1
30 9688884 Effects of short-term submaximal training in humans on muscle metabolism in exercise. 1998 Jul 2
31 9818465 [Lactate acidosis in childhood]. 1998 Sep 21 1
32 8598634 DNA diagnosis of pyruvate dehydrogenase deficiency in female patients with congenital lactic acidaemia. 1995 4
33 8076623 Effects of 2-chloropropionate on venous plasma lactate concentration and anaerobic power during periods of incremental intensive exercise in humans. 1994 3
34 8142598 Cachectin/TNF-mediated lactate production in cultured myocytes is linked to activation of a futile substrate cycle. 1993 Sep 2
35 1600837 Dichloroacetate. 1992 Jun 1
36 1736740 Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. 1992 Feb 3
37 2751069 Effect of sodium dichloroacetate on human pyruvate metabolism. 1989 3
38 3956111 Activation of human muscle pyruvate dehydrogenase with activity and immobilization. 1986 Feb 1