hydroxytamoxifen

cytochrome P450 family 2 subfamily D member 6 ; Homo sapiens







24 Article(s)
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1 31916635 Synthesis of novel flexible tamoxifen analogues to overcome CYP2D6 polymorphism and their biological evaluation on MCF-7 cell line. 2020 Jun 1
2 31398422 Corrigendum to "Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol" [Toxicology and Applied Pharmacology, 378 (2019) 114619]. 2019 Oct 1 1
3 29385237 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy. 2018 May 1
4 29436156 Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People. 2018 May 1
5 29245979 Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer. 2017 Nov 21 1
6 26446141 Augmentation of Endoxifen Exposure in Tamoxifen-Treated Women Following SSRI Switch. 2016 Feb 1
7 26896706 Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism. 2016 Apr 13 1
8 26898104 Design and synthesis of novel flexible ester-containing analogs of tamoxifen and their evaluation as anticancer agents. 2016 1
9 27198207 Multigene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19, and ABCB1. 2016 Dec 2
10 26071758 Boronic prodrug of endoxifen as an effective hormone therapy for breast cancer. 2015 Jul 1
11 24434530 Successful use of agomelatine in the treatment of major depression in a woman taking tamoxifen: a case report. 2014 Jan-Feb 2
12 24881593 Mitochondria: the gateway for tamoxifen-induced liver injury. 2014 Sep 2 1
13 25073551 Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes. 2014 Dec 2
14 25258390 Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients. 2014 Oct 1
15 23781139 Influence of CYP2D6 polymorphisms on serum levels of tamoxifen metabolites in Spanish women with breast cancer. 2013 1
16 21947681 Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients. 2012 Jan 5
17 21451508 Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma. 2011 May 1
18 21906462 The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review. 2011 Sep 1
19 20124171 Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. 2010 Mar 10 1
20 21086978 Tamoxifen metabolite isomer separation and quantification by liquid chromatography-tandem mass spectrometry. 2010 Dec 15 2
21 18294285 Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. 2008 May 3
22 18637494 Pharmacogenomics of endocrine therapy in breast cancer. 2008 2
23 12623757 CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes. 2003 Feb 1
24 12769667 Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. 2003 Jun 1