Imipramine

cytochrome P450 family 2 subfamily D member 6 ; Homo sapiens







20 Article(s)
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Pub. Year
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1 27632988 Computational Analysis of Physicochemical Factors Driving CYP2D6 Ligand Interaction. 2017 1
2 27440861 The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine. 2016 Oct 3
3 25719307 Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland. 2015 Sep 1
4 22764579 Comparison of catalytical activity and stereoselectivity between the recombinant human cytochrome P450 2D6.1 and 2D6.10. 2012 May 2
5 28520379 Imipramine Therapy and CYP2D6 and CYP2C19 Genotype 2012 1
6 19884907 The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients. 2010 Jun 1
7 17667959 Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients. 2008 Jun 9
8 18310890 Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain. 2008 Mar 3
9 15687478 QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. 2005 Mar 1
10 16141545 Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. 2005 Sep 2
11 12695349 Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions. 2003 May 1
12 12065442 Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. 2002 Jul 1
13 9205822 Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2. 1997 Jun 4
14 9256169 Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. 1997 Jun 15 2
15 9505989 Olanzapine: interaction study with imipramine. 1997 Oct 1
16 9512923 Synthetic strategies to lower affinity for CYP2D6. 1997 Oct-Dec 3
17 8835703 Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients. 1996 Aug 1
18 8521680 Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. 1995 Sep 1
19 8310712 Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line. 1993 Nov 3
20 8335704 Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability. 1993 Jun 2 3