| 1 |
35599345 | In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. | 2022 Jun |
1 |
| 2 |
33641805 | Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration. | 2021 Apr |
1 |
| 3 |
31925778 | Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. | 2020 Feb |
1 |
| 4 |
32198085 | Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. | 2020 May 1 |
1 |
| 5 |
30368994 | Mechanism-based inactivation of cytochrome P450 2D6 by chelidonine. | 2019 Feb |
1 |
| 6 |
31113867 | Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models. | 2019 Jun 28 |
1 |
| 7 |
31730751 | Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450. | 2019 Dec 16 |
1 |
| 8 |
29773554 | Nitidine Chloride Is a Mechanism-Based Inactivator of CYP2D6. | 2018 Aug |
1 |
| 9 |
30058787 | CYP2D6 basic genotyping as a potential tool to improve the antiemetic efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting. | 2018 Nov |
1 |
| 10 |
27756789 | Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants. | 2017 Jan |
2 |
| 11 |
28478356 | Dextromethorphan/quinidine pharmacotherapy in patients with treatment resistant depression: A proof of concept clinical trial. | 2017 Aug 15 |
1 |
| 12 |
25417051 | In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach. | 2016 Feb |
2 |
| 13 |
26452722 | Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes. | 2016 Jan |
1 |
| 14 |
26856397 | Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. | 2016 Mar |
1 |
| 15 |
25475885 | Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients. | 2015 Jan 1 |
1 |
| 16 |
25619394 | Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells. | 2015 Feb |
1 |
| 17 |
25719307 | Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland. | 2015 Sep |
1 |
| 18 |
26325084 | Does purified Swedish pollen extract, a nonhormonal treatment for vasomotor symptoms, inhibit the CYP2D6 enzyme system? | 2015 Nov |
2 |
| 19 |
25222611 | Nanocomposites of graphene and cytochrome P450 2D6 isozyme for electrochemical-driven tramadol metabolism. | 2014 Oct 7 |
1 |
| 20 |
27957038 | Cytochrome P450-2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following "Pill-in-the-Pocket" Quinidine plus Propafenone. | 2014 Feb-Mar |
1 |
| 21 |
23258538 | Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. | 2013 Feb 8 |
2 |
| 22 |
23340533 | Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain. | 2013 Jan |
2 |
| 23 |
24166670 | Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? | 2013 |
2 |
| 24 |
21508180 | Combined administration of quinidine and propafenone for atrial fibrillation: the CAQ-PAF study. | 2012 Feb |
2 |
| 25 |
21842479 | Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. | 2012 Mar |
1 |
| 26 |
21976621 | Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. | 2012 Jan |
1 |
| 27 |
22266842 | Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. | 2012 Apr |
1 |
| 28 |
22459173 | Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site. | 2012 May |
4 |
| 29 |
22675558 | Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49). | 2012 |
1 |
| 30 |
22688609 | Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro. | 2012 Sep |
1 |
| 31 |
28520381 | Metoprolol Therapy and CYP2D6 Genotype | 2012 |
1 |
| 32 |
21679153 | Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food. | 2011 Aug |
1 |
| 33 |
21722088 | Impact of impurities on IC50 values of P450 inhibitors. | 2011 Aug |
1 |
| 34 |
20041473 | Effect of metabolic blockade on the psychoactive effects of dextromethorphan. | 2010 Jan |
1 |
| 35 |
20345925 | Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells. | 2010 Apr |
4 |
| 36 |
20373255 | AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain. | 2010 Apr |
1 |
| 37 |
20388857 | Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity. | 2010 Jul |
2 |
| 38 |
20590587 | The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. | 2010 Jun |
1 |
| 39 |
19428327 | Stereoselective differences in the cytochrome P450-dependent dealkylation and demethylenation of N-methyl-benzodioxolyl-butanamine (MBDB, Eden) enantiomers. | 2009 Jun 1 |
1 |
| 40 |
19444798 | A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. | 2009 Nov |
1 |
| 41 |
17962373 | Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone. | 2008 Jan |
1 |
| 42 |
18026129 | Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions. | 2008 Mar |
1 |
| 43 |
18238857 | Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine. | 2008 May |
6 |
| 44 |
18346782 | Molecular modelling of human CYP2D6 and molecular docking of a series of ajmalicine- and quinidine-like inhibitors. | 2008 May 1 |
7 |
| 45 |
18356267 | Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions. | 2008 Jun |
1 |
| 46 |
18445989 | CYP2D6 is primarily responsible for the metabolism of clomiphene. | 2008 |
1 |
| 47 |
18448569 | Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans. | 2008 Aug |
1 |
| 48 |
18938231 | 2,5-Dimethoxyamphetamine-derived designer drugs: studies on the identification of cytochrome P450 (CYP) isoenzymes involved in formation of their main metabolites and on their capability to inhibit CYP2D6. | 2008 Dec 15 |
1 |
| 49 |
18974610 | A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method. | 2008 |
2 |
| 50 |
19000552 | Effect of CYP2D6 polymorphism on pharmacokinetics of a novel ACAT inhibitor, pactimibe and its unique metabolite, R-125528. | 2008 Nov |
1 |