phosphatidylinositol 3,5-diphosphate

VAC14 component of PIKFYVE complex ; Homo sapiens







24 Article(s)
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1 33248288 Expanding the spectrum of VAC14 related pediatric-onset neurological disease; striatonigral degeneration with brainstem involvement. 2021 Jan 3
2 34554760 Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID. 2021 Nov 5 1
3 31876398 Novel VAC14 variants identified in two Chinese siblings with childhood-onset striatonigral degeneration. 2020 Feb 2
4 32949958 Altered homodimer formation and increased iron accumulation in VAC14-related disease: Case report and review of the literature. 2020 Nov 2
5 33098764 Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex. 2020 Nov 19 1
6 33391314 Downregulating VAC14 in Guard Cells Causes Drought Hypersensitivity by Inhibiting Stomatal Closure. 2020 2
7 28635952 Yunis-Varón syndrome caused by biallelic VAC14 mutations. 2017 Sep 1
8 28857423 PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes. 2017 Nov 1
9 26934981 A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity. 2016 2
10 27292112 Biallelic Mutations of VAC14 in Pediatric-Onset Neurological Disease. 2016 Jul 7 1
11 26405034 The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation. 2015 Nov 20 1
12 24323921 Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. 2014 Jan 1
13 24578385 The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. 2014 Jun 1
14 23389034 Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. 2013 Mar 29 4
15 24070605 The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines. 2013 Oct 18 2
16 22842785 Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P. 2012 Aug 15 1
17 20630877 ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder. 2010 Aug 27 2
18 19578118 Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes. 2009 Sep 4 2
19 19840946 PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. 2009 Dec 18 1
20 18653468 Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. 2008 Oct 1
21 18950639 ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. 2008 Dec 26 2
22 17475247 ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. 2007 Jul 1 2
23 17556371 Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. 2007 Aug 17 3
24 15546865 Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway. 2005 Mar 4 1