Levodopa

catechol-O-methyltransferase ; Homo sapiens







290 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
51 26295926 Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability. 2015 Dec 2
52 24008922 Influence of single nucleotide polymorphisms in COMT, MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease. 2014 1
53 24148813 Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor. 2014 Feb 1
54 24271646 Effect of moderate liver impairment on the pharmacokinetics of opicapone. 2014 Mar 1
55 24716406 Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin. 2014 Mar 5
56 24770794 Fewer fluctuations, higher maximum concentration and better motor response of levodopa with catechol-O-methyltransferase inhibition. 2014 Nov 8
57 24830331 Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study. 2014 2
58 24925090 Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations. 2014 Sep 3
59 25154960 Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: flow-mediated dilation study. 2014 Oct 2
60 23206800 Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. 2013 Feb 25 3
61 23237479 Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism. 2013 Jul-Aug 1
62 23948989 Levodopa in the treatment of Parkinson's disease: current status and new developments. 2013 Jan 1 1
63 23994933 [Influence of levodopa, stalevo on dyskinesia in Parkinson's disease: STRIDE-PD study]. 2013 1
64 24234932 Association Between Catechol-O-Methyltransferase (COMT) Gene Polymorphisms, Parkinson's Disease, and Levodopa Efficacy. 2013 Nov 15 3
65 24532988 Pharmacogenetics of Parkinson's disease - through mechanisms of drug actions. 2013 Dec 1
66 22123108 Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review. 2012 Jan 13 2
67 22136069 Intestinal levodopa infusion and COMT inhibition - a promising link. 2012 Jun 1
68 22136163 Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial. 2012 Jun 3
69 22483291 Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment. 2012 May 4
70 22863920 Effects of 3-O-methyldopa, L-3,4-dihydroxyphenylalanine metabolite, on locomotor activity and dopamine turnover in rats. 2012 4
71 23020119 Protective effects of L-dopa and carbidopa combined treatments on human catecholaminergic cells. 2012 Nov 4
72 23093014 The catechol-O-methyltransferase and monoamine oxidase B polymorphisms and levodopa therapy in the Iranian patients with sporadic Parkinson's disease. 2012 2
73 21164341 Erythrocytes catechol-o-methyl transferase activity is up-regulated after a 3-month treatment by entacapone in parkinsonian patients. 2011 Jan-Feb 2
74 21280081 The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. 2011 Jan 5
75 21533995 Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease. 2011 Jun 4
76 21538606 Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors. 2011 May 27 3
77 21738693 Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor. 2011 1
78 22053701 Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease. 2011 Sep 2
79 22093536 Pharmacological treatment and the prospect of pharmacogenetics in Parkinson's disease. 2011 Dec 1
80 25205926 Cell based therapies in Parkinson's Disease. 2011 Apr 1
81 19676096 Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele. 2010 Mar 5 1
82 19879254 Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. 2010 Jan 14 1
83 19909787 Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa. 2010 Jan 14 2
84 20077469 The effect of peripheral enzyme inhibitors on levodopa concentrations in blood and CSF. 2010 Feb 15 1
85 20464572 Effect of entacapone on plasma homocysteine levels in Parkinson's disease patients. 2010 Oct 2
86 20582993 Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study. 2010 Jul 1
87 20700524 Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies. 2010 Aug 5 2
88 20812452 [The effect of Stalevo-dosing on quality of life of Parkinsonian patients with wearing-off]. 2010 Jul 30 1
89 20856911 Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo). 2010 Sep 7 2
90 21095456 Introductory remarks: Catechol-O-methyltransferase inhibition--an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition. 2010 11
91 21095459 Catechol-O-methyltransferase enzyme: cofactor S-adenosyl-L-methionine and related mechanisms. 2010 1
92 21095461 The chemistry of catechol-O-methyltransferase inhibitors. 2010 2
93 21095462 Toxicology and safety of COMT inhibitors. 2010 2
94 21095464 Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease. 2010 1
95 19056347 Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor. 2009 Jan 16 2
96 19131039 L-dopa therapy for Parkinson's disease: past, present, and future. 2009 Jan 2
97 19167259 Pharmacologic treatment of advanced Parkinson's disease: a meta-analysis of COMT inhibitors and MAO-B inhibitors. 2009 Aug 1
98 19407449 Levodopa: past, present, and future. 2009 2
99 19538218 Levodopa in the treatment of Parkinson's disease. 2009 Sep 1
100 19589043 Levodopa/carbidopa/entacapone in Parkinson's disease. 2009 Jul 4