| 1 |
32691671 | Prospecting for new catechol-O-methyltransferase (COMT) inhibitors as a potential treatment for Parkinson's disease: a study by molecular dynamics and structure-based virtual screening. | 2021 Oct |
2 |
| 2 |
34027136 | Interaction of silver nanoparticles with catechol O-methyltransferase: Spectroscopic and simulation analyses. | 2021 Jul |
1 |
| 3 |
34679357 | Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs. | 2021 Sep 29 |
2 |
| 4 |
31708229 | Neurological and psychiatric management using COMT inhibitors: A review. | 2020 Jan |
1 |
| 5 |
31869215 | Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols. | 2020 Jan 8 |
2 |
| 6 |
32371482 | Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction. | 2020 May 19 |
2 |
| 7 |
32378542 | Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone. | 2020 |
8 |
| 8 |
32492152 | Nano-second protein dynamics of key residue at Position 38 in catechol-O-methyltransferase system: a time-resolved fluorescence study. | 2020 Oct 1 |
4 |
| 9 |
30935952 | The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase. | 2019 Jun |
1 |
| 10 |
30157632 | Catalytic Reaction Mechanism in Native and Mutant Catechol- O-methyltransferase from the Adaptive String Method and Mean Reaction Force Analysis. | 2018 Sep 27 |
1 |
| 11 |
27826992 | The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols. | 2017 Feb |
2 |
| 12 |
27939670 | Identification and characterization of a catechol-o-methyltransferase cDNA in the catfish Heteropneustes fossilis: Tissue, sex and seasonal variations, and effects of gonadotropin and 2-hydroxyestradiol-17β on mRNA expression. | 2017 May 15 |
1 |
| 13 |
27981425 | 1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol. | 2017 Apr |
2 |
| 14 |
28448141 | Correction to Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket. | 2017 May 11 |
1 |
| 15 |
27685665 | Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket. | 2016 Nov 23 |
1 |
| 16 |
25159911 | Linking electrostatic effects and protein motions in enzymatic catalysis. A theoretical analysis of catechol o-methyltransferase. | 2015 Jan 22 |
2 |
| 17 |
25388538 | Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization. | 2015 Feb |
2 |
| 18 |
26253436 | Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis. | 2015 Sep 30 |
2 |
| 19 |
24847974 | A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). | 2014 Jun 26 |
2 |
| 20 |
24450388 | Inhibitors of catechol-O-methyltransferase in the treatment of neurological disorders. | 2013 |
2 |
| 21 |
22349227 | Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors. | 2012 Mar |
1 |
| 22 |
23056605 | How metal substitution affects the enzymatic activity of catechol-o-methyltransferase. | 2012 |
2 |
| 23 |
21304959 | Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. | 2011 Jan 31 |
4 |
| 24 |
21538606 | Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors. | 2011 May 27 |
3 |
| 25 |
21904625 | Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. | 2011 |
1 |
| 26 |
21958159 | Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency. | 2011 Nov 2 |
4 |
| 27 |
21154325 | [Association of genetic polymorphisms of COMT gene with psychiatric disorders]. | 2010 Dec |
2 |
| 28 |
18824331 | Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia. | 2009 Jan |
1 |
| 29 |
19077667 | Identification of a novel haplotype of the human catechol-O-methyltransferase gene. | 2009 Jan |
2 |
| 30 |
18474266 | The V108M mutation decreases the structural stability of catechol O-methyltransferase. | 2008 Jul-Aug |
2 |
| 31 |
18486144 | Crystal structures of human 108V and 108M catechol O-methyltransferase. | 2008 Jun 27 |
2 |
| 32 |
19020775 | Characterization of a novel human catechol-O-methyl-transferase mutant with triplet point mutations. | 2008 Dec |
3 |
| 33 |
17724020 | S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase. | 2007 Oct 19 |
1 |
| 34 |
17880176 | Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases. | 2007 Oct |
2 |
| 35 |
17907785 | NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine. | 2007 Nov |
2 |
| 36 |
18064318 | Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. | 2007 Dec |
2 |
| 37 |
16475806 | The 108M polymorph of human catechol O-methyltransferase is prone to deformation at physiological temperatures. | 2006 Feb 21 |
6 |
| 38 |
16618795 | Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation. | 2006 Jul |
1 |
| 39 |
15614425 | The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats. | 2005 Sep |
4 |
| 40 |
16045352 | On the nature of the transition state in catechol O-methyltransferase. A complementary study based on molecular dynamics and potential energy surface explorations. | 2005 Aug 3 |
1 |
| 41 |
16340382 | Levodopa intake increases plasma levels of S-adenosylmethionine in treated patients with Parkinson disease. | 2005 Nov-Dec |
2 |
| 42 |
15124004 | Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families. | 2004 Oct |
2 |
| 43 |
12533089 | Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease. | 2003 Jan |
1 |
| 44 |
12842102 | High-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection. | 2003 Aug 1 |
1 |
| 45 |
12075857 | 3-OMD and homocysteine plasma levels in parkinsonian patients. | 2002 Feb |
4 |
| 46 |
12450669 | Separation methods for catechol O-methyltransferase activity assay: physiological and pathophysiological relevance. | 2002 Dec 5 |
2 |
| 47 |
11223018 | COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro. | 2001 Mar 2 |
1 |
| 48 |
11577006 | COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk. | 2001 Oct |
5 |
| 49 |
10692500 | Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. | 2000 Mar |
1 |
| 50 |
10950844 | O-Methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase. | 2000 Sep |
2 |