Esters

carboxylesterase 2 ; Homo sapiens







25 Article(s)
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1 33421954 Discovery of Thai mangrove tetranortriterpenoids as agonists of human pregnane-X-receptor and inhibitors against human carboxylesterase 2. 2021 Feb 1
2 32115554 [Evaluation of the Oral Absorption of Ester-type Prodrugs]. 2020 1
3 32123952 Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system. 2020 Apr 2
4 30867471 Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma. 2019 Mar 13 1
5 31260759 Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening. 2019 Sep 15 1
6 31323527 Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors. 2019 Oct 3
7 29421708 Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2. 2018 Apr 1
8 29709907 Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies. 2018 3
9 26750665 Gambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2. 2016 Sep 1
10 26825642 Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. 2016 Jul 1
11 26900660 Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. 2016 Apr 13 1
12 27149931 Tissue-infiltrating plasma cells are an important source of carboxylesterase 2 contributing to the therapeutic efficacy of prodrugs. 2016 Aug 1 2
13 24141856 In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors. 2014 Jan 1
14 24461291 Undesired versus designed enzymatic cleavage of linkers for liver targeting. 2014 Feb 15 1
15 24988246 The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect. 2014 2
16 25303639 Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent. 2014 Dec 1 2
17 21237253 Lipopolysaccharide down-regulates carbolesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway. 2011 Mar 25 1
18 20623318 Homology modeling and metabolism prediction of human carboxylesterase-2 using docking analyses by GriDock: a parallelized tool based on AutoDock 4.0. 2010 Sep 1
19 17537833 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. 2007 Sep 1
20 17640957 Haplotypes and a novel defective allele of CES2 found in a Japanese population. 2007 Oct 2
21 16011259 [Stereoselectivity of skin carboxylesterase metabolism]. 2005 Apr 1
22 12607608 Comprehensive evaluation of carboxylesterase-2 expression in normal human tissues using tissue array analysis. 2002 Dec 1
23 9169443 Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. 1997 Jun 6 1
24 9300133 Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. 1997 Aug 1
25 8930175 Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases. 1996 Nov 1