MK 0591

arachidonate 5-lipoxygenase ; Homo sapiens







11 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 32313135 Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis. 2020 Apr 20 2
2 30728896 Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N-terminal kinase. 2019 Jan 11 3
3 25540201 Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells. 2015 Feb 20 2
4 21824498 Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon. 2011 Dec 2
5 19906484 MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase. 2010 May 28 1
6 10531413 Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4). 1999 Nov 1
7 9507210 Regulatory interactions between inducible nitric oxide synthase and eicosanoids in glomerular immune injury. 1998 Mar 1
8 9041233 Leukotrienes in ulcerative colitis: results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591. 1997 Mar 1
9 7697951 Blockade of leukotriene production by a single oral dose of MK-0591 in active ulcerative colitis. 1995 Mar 2
10 7822663 The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. 1995 Jan 2
11 8033491 Pharmacokinetics and pharmacodynamics of multiple oral doses of MK-0591, a 5-lipoxygenase-activating protein inhibitor. 1994 Jul 1