| 51 |
29229677 | Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages. | 2018 Jan 15 |
3 |
| 52 |
29805660 | Association between 5-lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma. | 2018 Jun |
2 |
| 53 |
29890138 | Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method. | 2018 Oct 7 |
1 |
| 54 |
29928483 | miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. | 2018 Jun 1 |
1 |
| 55 |
30015253 | Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. | 2018 Jul 15 |
1 |
| 56 |
30053720 | Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. | 2018 Aug 5 |
2 |
| 57 |
30248405 | Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm. | 2018 Nov |
2 |
| 58 |
30254055 | MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. | 2018 Sep 25 |
1 |
| 59 |
30392579 | 5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity. | 2018 Nov |
1 |
| 60 |
27883201 | Effect of treatment with 5-lipoxygenase inhibitor VIA-2291 (atreleuton) on coronary plaque progression: a serial CT angiography study. | 2017 Apr |
1 |
| 61 |
28005436 | Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. | 2017 May |
2 |
| 62 |
28125014 | Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. | 2017 Jan 24 |
1 |
| 63 |
28218273 | Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. | 2017 Feb 20 |
2 |
| 64 |
28257804 | Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. | 2017 May |
1 |
| 65 |
28569429 | CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway. | 2017 Jul 6 |
1 |
| 66 |
28623130 | Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia. | 2017 Aug 19 |
2 |
| 67 |
28647490 | Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy. | 2017 Dec 1 |
1 |
| 68 |
28680195 | New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis. | 2017 |
2 |
| 69 |
28803964 | TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation. | 2017 Nov |
2 |
| 70 |
28839250 | Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. | 2017 Aug 24 |
3 |
| 71 |
26396238 | Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes. | 2016 Jan |
3 |
| 72 |
26456699 | The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog. | 2016 Jan |
1 |
| 73 |
26541818 | The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation. | 2016 Mar |
1 |
| 74 |
26549540 | Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? | 2016 Jan |
1 |
| 75 |
26904397 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase. | 2016 Jan |
3 |
| 76 |
26944113 | Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. | 2016 Mar 15 |
2 |
| 77 |
26979937 | Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. | 2016 May |
1 |
| 78 |
27010627 | Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs. | 2016 |
1 |
| 79 |
27033421 | Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils. | 2016 Apr |
1 |
| 80 |
27157409 | The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. | 2016 Jul 15 |
2 |
| 81 |
27347071 | Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways. | 2016 Jul |
4 |
| 82 |
27363940 | Kinetic investigation of human 5-lipoxygenase with arachidonic acid. | 2016 Aug 1 |
1 |
| 83 |
27423639 | Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. | 2016 Oct 21 |
1 |
| 84 |
27592027 | BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly. | 2016 Nov 1 |
4 |
| 85 |
27635633 | A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress-Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells. | 2016 Sep 1 |
2 |
| 86 |
27708579 | Pharmacogenomics of Prostaglandin and Leukotriene Receptors. | 2016 |
1 |
| 87 |
27855198 | Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase. | 2016 |
1 |
| 88 |
27990118 | Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. | 2016 |
2 |
| 89 |
29648709 | INHIBITORS OF LEUKOTRIENES SYNTHESIS: NOVEL AGENTS AND THEIR IMPLEMENTATION. | 2016 Jul |
2 |
| 90 |
24662827 | Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. | 2015 Mar 5 |
2 |
| 91 |
25152163 | 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. | 2015 Apr |
3 |
| 92 |
25462262 | Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. | 2015 Jan 7 |
1 |
| 93 |
25589070 | 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. | 2015 Feb 15 |
1 |
| 94 |
25681061 | Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes. | 2015 Apr |
2 |
| 95 |
25733811 | Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents. | 2015 |
1 |
| 96 |
25752438 | A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome. | 2015 May |
1 |
| 97 |
25912480 | Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenase. | 2015 Aug |
2 |
| 98 |
26040270 | Synthesis and Biological Evaluation of N-Aryl-5-aryloxazol-2-amine Derivatives as 5-Lipoxygenase Inhibitors. | 2015 |
2 |
| 99 |
26070487 | 5-Lipoxygenase is a direct p53 target gene in humans. | 2015 Aug |
2 |
| 100 |
26173130 | The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart. | 2015 |
2 |