| 451 |
1309376 | Increased excretion of leukotriene E4 during aspirin-induced asthma. | 1992 Jan |
1 |
| 452 |
1309444 | Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation. | 1992 Jan |
2 |
| 453 |
1313879 | Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase. | 1992 Apr 3 |
1 |
| 454 |
1323665 | Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil. | 1992 Aug |
2 |
| 455 |
1357659 | Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family. | 1992 Oct 1 |
2 |
| 456 |
1359745 | 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease. | 1992 |
2 |
| 457 |
1375926 | Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. | 1992 |
1 |
| 458 |
1413091 | Designing therapeutically effective 5-lipoxygenase inhibitors. | 1992 Aug |
2 |
| 459 |
1469057 | A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. | 1992 Dec |
1 |
| 460 |
1541284 | Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation. | 1992 Mar 1 |
1 |
| 461 |
1588922 | Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition. | 1992 May |
1 |
| 462 |
1618602 | The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. | 1992 Apr |
1 |
| 463 |
1659156 | Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. | 1991 Jul |
2 |
| 464 |
1748650 | Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. | 1991 Dec 15 |
1 |
| 465 |
1781415 | Pharmacokinetics, safety, and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase. | 1991 |
1 |
| 466 |
1848819 | Effects of monocyte-lymphocyte interaction on the synthesis of leukotriene B4. | 1991 Mar 14 |
1 |
| 467 |
1851340 | Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. | 1991 Mar |
1 |
| 468 |
1857337 | 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. | 1991 Jul |
2 |
| 469 |
1900463 | Absence of modulation of monokine production via endogenous cyclooxygenase or 5-lipoxygenase metabolites: MK-886 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid), indomethacin, or arachidonate fail to alter immunoreactive interleukin-1 beta, or TNF-alpha production by human monocytes in vitro. | 1991 Mar |
1 |
| 470 |
1901823 | "Enzymatic" lipid peroxidation: reactions of mammalian lipoxygenases. | 1991 |
1 |
| 471 |
1907059 | Arachidonic acid metabolism: role in inflammation. | 1991 |
1 |
| 472 |
1998235 | [Leukotrienes. A review of the significance for disease in man and the possibilities for therapeutic intervention]. | 1991 Jan 14 |
3 |
| 473 |
2024291 | FLAP: a novel drug target for inhibiting the synthesis of leukotrienes. | 1991 Feb |
4 |
| 474 |
1701029 | Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. | 1990 Dec 20 |
1 |
| 475 |
1965768 | Functional consequences of phospholipase A2 activation in human monocytes. | 1990 |
1 |
| 476 |
2104841 | MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. | 1990 Jan 25 |
2 |
| 477 |
2108450 | Leukotrienes and inflammation. | 1990 |
1 |
| 478 |
2128178 | Effects of novel antifungal azole derivatives on the 5-lipoxygenase and cyclooxygenase pathway. | 1990 Nov |
1 |
| 479 |
2156049 | Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury. | 1990 Feb |
1 |
| 480 |
2166915 | Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. | 1990 Sep 6 |
1 |
| 481 |
2174753 | Biosynthesis and biological activity of leukotriene B4. | 1990 Oct |
1 |
| 482 |
2300172 | Identification and isolation of a membrane protein necessary for leukotriene production. | 1990 Jan 18 |
1 |
| 483 |
2300173 | Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. | 1990 Jan 18 |
2 |
| 484 |
2308140 | Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent. | 1990 Mar |
1 |
| 485 |
2492639 | Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel. | 1989 Feb 9 |
2 |
| 486 |
2502629 | Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. | 1989 Aug |
1 |
| 487 |
2572437 | Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. | 1989 Oct 10 |
1 |
| 488 |
2649885 | Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system. | 1989 Apr |
1 |
| 489 |
2650691 | n-3 fatty acids and leucocytes. | 1989 |
1 |
| 490 |
2709371 | 2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis. | 1989 May |
1 |
| 491 |
2919414 | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 Feb |
4 |
| 492 |
2829172 | Molecular cloning and amino acid sequence of human 5-lipoxygenase. | 1988 Jan |
1 |
| 493 |
2833396 | Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4. | 1988 Apr 5 |
1 |
| 494 |
2842416 | Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis. | 1988 Sep |
1 |
| 495 |
2844372 | Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. | 1988 Jun |
1 |
| 496 |
2845484 | 5-Lipoxygenase and leukotriene synthesis: effects of calcium ions and of inhibitors. | 1988 Jul |
2 |
| 497 |
2849922 | In vitro inhibition of leukotriene B4 formation by exogeneous 5-lipoxygenase inhibitors is associated with enhanced generation of 15-hydroxy-eicosatetraenoic acid (15-HETE) by human neutrophils. | 1988 |
1 |
| 498 |
3140617 | Modulation of arachidonic acid metabolites as potential therapy of asthma. | 1988 |
1 |
| 499 |
3164719 | Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells. | 1988 Jul 25 |
1 |
| 500 |
3422434 | Cloning of the cDNA for human 5-lipoxygenase. | 1988 Jan |
1 |