526 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 34387870 | CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase. | 2022 Jan | 2 |
2 | 34762841 | Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages. | 2022 Jan | 1 |
3 | 34896589 | Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management. | 2022 Jan | 2 |
4 | 35173459 | Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201. | 2022 | 4 |
5 | 35300294 | Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors. | 2022 | 1 |
6 | 35461365 | Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia. | 2022 Jun | 2 |
7 | 33568930 | Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2? | 2021 | 2 |
8 | 33818747 | Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury. | 2021 Oct | 2 |
9 | 34086061 | The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications. | 2021 Aug | 2 |
10 | 34279935 | Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. | 2021 Aug 12 | 1 |
11 | 34360703 | Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review. | 2021 Jul 25 | 2 |
12 | 34401905 | Eicosanoid receptors as therapeutic targets for asthma. | 2021 Aug 27 | 2 |
13 | 34411565 | Role of eicosanoids in liver repair, regeneration and cancer. | 2021 Oct | 2 |
14 | 34560079 | Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. | 2021 | 1 |
15 | 34971430 | Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood. | 2021 Dec 31 | 1 |
16 | 35126121 | Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport. | 2021 | 2 |
17 | 31841698 | Zileuton use and phenotypic features in asthma. | 2020 Feb | 1 |
18 | 32041263 | The Potential of Telomeric G-quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils. | 2020 Feb 6 | 1 |
19 | 32072462 | The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies. | 2020 Jul | 1 |
20 | 32096311 | Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics. | 2020 Oct | 1 |
21 | 32120263 | LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells. | 2020 Mar | 2 |
22 | 32171526 | The role of propofol hydroxyl group in 5-lipoxygenase recognition. | 2020 May 14 | 2 |
23 | 32257113 | A new treatment for severe pulmonary arterial hypertension based on an old idea: inhibition of 5-lipoxygenase. | 2020 Jan-Mar | 1 |
24 | 32306507 | Inhibition of 5-Lipoxygenase-Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins. | 2020 Jun | 1 |
25 | 32668380 | Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. | 2020 Sep 15 | 2 |
26 | 32671628 | Phosphorylation of 5-LOX: The Potential Set-point of Inflammation. | 2020 Oct | 2 |
27 | 32678115 | HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. | 2020 Jul 16 | 2 |
28 | 32771067 | Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. | 2020 Aug 8 | 4 |
29 | 32799052 | A cheminformatic study on chemical space characterization and diversity analysis of 5-LOX inhibitors. | 2020 Nov | 2 |
30 | 33364964 | Eicosanoids in Cancer: New Roles in Immunoregulation. | 2020 | 1 |
31 | 30238827 | G-quadruplex-forming oligodeoxyribonucleotides activate leukotriene synthesis in human neutrophils. | 2019 Sep | 2 |
32 | 30291962 | A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. | 2019 Apr | 1 |
33 | 30352167 | Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. | 2019 Apr | 1 |
34 | 30415966 | Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. | 2019 Jan 17 | 3 |
35 | 30471171 | Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. | 2019 Jan 22 | 1 |
36 | 30638966 | Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies. | 2019 Feb 15 | 2 |
37 | 30678465 | Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial. | 2019 May | 1 |
38 | 30735438 | Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome. | 2019 May | 4 |
39 | 30869888 | Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. | 2019 May 9 | 1 |
40 | 30930090 | Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase. | 2019 Jun | 2 |
41 | 31260889 | Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. | 2019 Oct 1 | 2 |
42 | 31316498 | Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation. | 2019 | 1 |
43 | 31331653 | 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. | 2019 Sep 1 | 4 |
44 | 31523435 | Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells. | 2019 Oct | 2 |
45 | 31664810 | Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5. | 2019 Dec 20 | 1 |
46 | 31687975 | Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. | 2019 Dec 19 | 1 |
47 | 31871543 | Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. | 2019 | 1 |
48 | 28699354 | Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. | 2018 May 10 | 1 |
49 | 28784429 | Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. | 2018 Jun 10 | 4 |
50 | 29133059 | Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma. | 2018 Jun 10 | 1 |