Leukotrienes

arachidonate 5-lipoxygenase ; Homo sapiens







526 Article(s)
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1 34387870 CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase. 2022 Jan 2
2 34762841 Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages. 2022 Jan 1
3 34896589 Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management. 2022 Jan 2
4 35173459 Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201. 2022 4
5 35300294 Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors. 2022 1
6 35461365 Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia. 2022 Jun 2
7 33568930 Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2? 2021 2
8 33818747 Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury. 2021 Oct 2
9 34086061 The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications. 2021 Aug 2
10 34279935 Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. 2021 Aug 12 1
11 34360703 Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review. 2021 Jul 25 2
12 34401905 Eicosanoid receptors as therapeutic targets for asthma. 2021 Aug 27 2
13 34411565 Role of eicosanoids in liver repair, regeneration and cancer. 2021 Oct 2
14 34560079 Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. 2021 1
15 34971430 Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood. 2021 Dec 31 1
16 35126121 Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport. 2021 2
17 31841698 Zileuton use and phenotypic features in asthma. 2020 Feb 1
18 32041263 The Potential of Telomeric G-quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils. 2020 Feb 6 1
19 32072462 The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies. 2020 Jul 1
20 32096311 Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics. 2020 Oct 1
21 32120263 LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells. 2020 Mar 2
22 32171526 The role of propofol hydroxyl group in 5-lipoxygenase recognition. 2020 May 14 2
23 32257113 A new treatment for severe pulmonary arterial hypertension based on an old idea: inhibition of 5-lipoxygenase. 2020 Jan-Mar 1
24 32306507 Inhibition of 5-Lipoxygenase-Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins. 2020 Jun 1
25 32668380 Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. 2020 Sep 15 2
26 32671628 Phosphorylation of 5-LOX: The Potential Set-point of Inflammation. 2020 Oct 2
27 32678115 HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. 2020 Jul 16 2
28 32771067 Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. 2020 Aug 8 4
29 32799052 A cheminformatic study on chemical space characterization and diversity analysis of 5-LOX inhibitors. 2020 Nov 2
30 33364964 Eicosanoids in Cancer: New Roles in Immunoregulation. 2020 1
31 30238827 G-quadruplex-forming oligodeoxyribonucleotides activate leukotriene synthesis in human neutrophils. 2019 Sep 2
32 30291962 A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. 2019 Apr 1
33 30352167 Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. 2019 Apr 1
34 30415966 Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. 2019 Jan 17 3
35 30471171 Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. 2019 Jan 22 1
36 30638966 Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies. 2019 Feb 15 2
37 30678465 Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial. 2019 May 1
38 30735438 Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome. 2019 May 4
39 30869888 Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. 2019 May 9 1
40 30930090 Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase. 2019 Jun 2
41 31260889 Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. 2019 Oct 1 2
42 31316498 Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation. 2019 1
43 31331653 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. 2019 Sep 1 4
44 31523435 Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells. 2019 Oct 2
45 31664810 Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5. 2019 Dec 20 1
46 31687975 Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. 2019 Dec 19 1
47 31871543 Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. 2019 1
48 28699354 Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. 2018 May 10 1
49 28784429 Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. 2018 Jun 10 4
50 29133059 Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma. 2018 Jun 10 1