| 1 |
30819230 | TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling. | 2019 Feb 28 |
1 |
| 2 |
23762565 | 5-lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte. | 2013 |
2 |
| 3 |
24168271 | Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection. | 2013 Oct 30 |
1 |
| 4 |
22068350 | COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes. | 2012 Jan |
1 |
| 5 |
22293202 | Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. | 2012 Feb 24 |
1 |
| 6 |
21643005 | A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. | 2011 Jul |
1 |
| 7 |
21993002 | Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors. | 2011 Oct |
2 |
| 8 |
20061081 | Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. | 2010 Jun 28 |
1 |
| 9 |
20126469 | A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. | 2010 Feb |
2 |
| 10 |
20364155 | A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase. | 2010 May |
1 |
| 11 |
20567598 | Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. | 2010 Jun 17 |
1 |
| 12 |
19239910 | MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation. | 2009 Apr 17 |
3 |
| 13 |
18771933 | Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. | 2008 Nov 13 |
1 |
| 14 |
17319946 | Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARgamma activation in human gingival fibroblasts. | 2007 Feb 23 |
1 |
| 15 |
16545574 | Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin. | 2006 Aug 1 |
1 |
| 16 |
16547963 | Intrapulmonary application of a 5-lipoxygenase inhibitor using surfactant as a carrier reduces lung edema in a piglet model of airway lavage. | 2006 May |
1 |
| 17 |
16551867 | Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886. | 2006 Mar 15 |
1 |
| 18 |
17121918 | Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. | 2006 Nov |
1 |
| 19 |
15454480 | Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells. | 2005 Feb 1 |
1 |
| 20 |
15630695 | AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities. | 2005 |
1 |
| 21 |
15899809 | Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. | 2005 May 15 |
1 |
| 22 |
14656710 | Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. | 2004 Apr |
1 |
| 23 |
15132836 | Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells. | 2004 May |
1 |
| 24 |
15517864 | Acute changes in U937 nuclear Ca2+ preceding type 1 "apoptotic" programmed cell death due to MK 886. | 2004 Sep-Oct |
1 |
| 25 |
12660222 | Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. | 2003 Apr |
1 |
| 26 |
12033433 | Fatty acid oxidation and signaling in apoptosis. | 2002 Mar-Apr |
1 |
| 27 |
12054916 | Increased cytosol Ca(2+) and type 1 programmed cell death in Bcl-2-positive U937 but not in Bcl-2-negative PC-3 and Panc-1 cells induced by the 5-lipoxygenase inhibitor MK 886. | 2002 Apr |
3 |
| 28 |
12394960 | Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. | 2002 Oct |
1 |
| 29 |
11311496 | The mode of cell death in H-358 lung cancer cells cultured with inhibitors of 5-lipoxygenase or the free radical spin trap, NTBN. | 2001 May 26 |
1 |
| 30 |
11333152 | Impact of MK-886 on H2O2 generation by human neutrophils and cell degranulation. | 2001 Mar |
1 |
| 31 |
10913156 | Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. | 2000 Oct 13 |
1 |
| 32 |
10953307 | A genomic response of H-358 bronchiolar carcinoma cells to MK 886, an inhibitor of 5-lipoxygenase, assessed with a cDNA array. | 2000 Jul-Aug |
1 |
| 33 |
10493497 | The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. | 1999 Sep 15 |
1 |
| 34 |
10600493 | The early phase of apoptosis in human neuroblastoma CHP100 cells is characterized by lipoxygenase-dependent ultraweak light emission. | 1999 Nov 30 |
1 |
| 35 |
10628326 | Altered oncogene, tumor suppressor and cell-cycle gene expression in PANC-1 cells cultured with the pleiotrophic 5-lipoxygenase inhibitor, MK886, assessed with a gene chip. | 1999 Sep-Oct |
1 |
| 36 |
9550202 | Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. | 1998 Mar |
1 |
| 37 |
9585079 | MK-886, a leukotriene biosynthesis inhibitor, induces antiproliferative effects and apoptosis in HL-60 cells. | 1998 Jan |
1 |
| 38 |
9615721 | Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. | 1998 Mar-Apr |
2 |
| 39 |
9639560 | Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade. | 1998 Jul 1 |
1 |
| 40 |
9696418 | Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells. | 1998 Jun 5 |
2 |
| 41 |
9742967 | Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells. | 1998 Sep 4 |
1 |
| 42 |
9789062 | Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. | 1998 Oct 27 |
1 |
| 43 |
9792133 | 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death. | 1998 Nov 1 |
1 |
| 44 |
9845549 | Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. | 1998 Dec 15 |
1 |
| 45 |
9044439 | A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death. | 1997 Jan |
1 |
| 46 |
9103531 | Inhibition by boswellic acids of human leukocyte elastase. | 1997 Apr |
1 |
| 47 |
9261338 | 5-Lipoxygenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells. | 1997 Aug |
1 |
| 48 |
9435558 | Modulation of P-selectin expression in the postischemic intestinal microvasculature. | 1997 Dec |
1 |
| 49 |
8917356 | An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells. | 1996 Sep-Oct |
3 |
| 50 |
7484419 | Ovulation as a tissue remodelling process. Proteolysis and cumulus expansion. | 1995 |
1 |