| 1 |
33818747 | Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury. | 2021 Oct |
1 |
| 2 |
33940184 | Evaluation of inhibitors of the arachidonic acid cascade with intact platelets using an on-line dilution and on-line solid phase extraction HPLC-MS method. | 2021 Aug |
1 |
| 3 |
34086061 | The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications. | 2021 Aug |
1 |
| 4 |
34249079 | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs. | 2021 |
1 |
| 5 |
34429873 | Biomarkers for predicting response to long-term high dose aspirin therapy in aspirin-exacerbated respiratory disease. | 2021 Aug |
1 |
| 6 |
34560079 | Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. | 2021 |
1 |
| 7 |
34604848 | Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2. | 2021 Sep 27 |
3 |
| 8 |
31841698 | Zileuton use and phenotypic features in asthma. | 2020 Feb |
1 |
| 9 |
32222525 | 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease. | 2020 Aug |
2 |
| 10 |
32240653 | Targeting the OXE receptor as a potential novel therapy for asthma. | 2020 Sep |
1 |
| 11 |
32439596 | The role of the LTB4-BLT1 axis in health and disease. | 2020 Aug |
1 |
| 12 |
32601404 | A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors. | 2020 Jun 29 |
2 |
| 13 |
32645009 | Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions. | 2020 |
1 |
| 14 |
32668380 | Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. | 2020 Sep 15 |
1 |
| 15 |
32707371 | Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS. | 2020 Oct |
2 |
| 16 |
33263931 | Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder. | 2020 Dec |
2 |
| 17 |
30389631 | A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease. | 2019 Jan 5 |
2 |
| 18 |
30415966 | Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. | 2019 Jan 17 |
1 |
| 19 |
30471171 | Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. | 2019 Jan 22 |
1 |
| 20 |
30735438 | Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome. | 2019 May |
3 |
| 21 |
31331653 | 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. | 2019 Sep 1 |
2 |
| 22 |
31664810 | Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5. | 2019 Dec 20 |
1 |
| 23 |
31871543 | Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. | 2019 |
3 |
| 24 |
28784429 | Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. | 2018 Jun 10 |
6 |
| 25 |
28786533 | MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5. | 2018 Feb |
2 |
| 26 |
29133059 | Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma. | 2018 Jun 10 |
1 |
| 27 |
29805660 | Association between 5-lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma. | 2018 Jun |
2 |
| 28 |
29928483 | miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. | 2018 Jun 1 |
1 |
| 29 |
30248405 | Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm. | 2018 Nov |
1 |
| 30 |
30392579 | 5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity. | 2018 Nov |
1 |
| 31 |
30407793 | 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. | 2018 Dec 4 |
2 |
| 32 |
30410359 | Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway. | 2018 |
2 |
| 33 |
28069825 | Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. | 2017 Apr |
2 |
| 34 |
28125014 | Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. | 2017 Jan 24 |
1 |
| 35 |
28340986 | Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. | 2017 Jan 1 |
1 |
| 36 |
28569429 | CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway. | 2017 Jul 6 |
1 |
| 37 |
28803964 | TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation. | 2017 Nov |
2 |
| 38 |
28887514 | Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. | 2017 Sep 8 |
1 |
| 39 |
28892009 | Nrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells. | 2017 Sep 11 |
1 |
| 40 |
28932020 | Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases. | 2017 |
1 |
| 41 |
29042025 | Biosynthesis of leukotriene B4. | 2017 Oct |
2 |
| 42 |
29199960 | Update on the Genetic Basis of Drug Hypersensitivity Reactions. | 2017 |
1 |
| 43 |
29376243 | [Discover potential inhibitors of 5-LOX and LTA4H from Rhei Radix et Rhizoma, Notopterygii Rhizoma et Radix and Genitana Macrophyllae Radix based on molecular simulation methods]. | 2017 Dec |
3 |
| 44 |
26541818 | The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation. | 2016 Mar |
1 |
| 45 |
26944113 | Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. | 2016 Mar 15 |
2 |
| 46 |
26997150 | The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. | 2016 |
2 |
| 47 |
27033421 | Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils. | 2016 Apr |
1 |
| 48 |
27203112 | The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. | 2016 May 19 |
2 |
| 49 |
27312808 | Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. | 2016 Oct |
1 |
| 50 |
27363940 | Kinetic investigation of human 5-lipoxygenase with arachidonic acid. | 2016 Aug 1 |
1 |