Simvastatin

interferon gamma ; Homo sapiens







25 Article(s)
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1 34687147 Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells. 2022 Mar 1
2 27343379 Simvastatin requires activation in accessory cells to modulate T-cell responses in asthma and COPD. 2016 Oct 5 2
3 25659387 Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway. 2015 Feb 1
4 24419251 Simvastatin inhibits cytokines in a dose response in patients with rheumatoid arthritis. 2014 Apr 1
5 24788303 Simvastatin modulates cellular components in influenza A virus-infected cells. 2014 Jul 1
6 23950601 Lymphocyte-suppressing action of simvastatin in patients with isolated hypertriglyceridemia. 2013 1
7 24159421 Statin Modulation of Human T-Cell Proliferation, IL-1β and IL-17 Production, and IFN-γ T Cell Expression: Synergy with Conventional Immunosuppressive Agents. 2013 1
8 23042198 Simvastatin protects against T cell immune dysfunction in abdominal sepsis. 2012 Nov 1
9 23107042 Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose. 2012 Dec 1
10 21268089 Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. 2011 Feb 2
11 21276586 Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia. 2011 Apr 1 1
12 21440087 Statins as modulators of colon cancer cells induced cytokine secretion by human PBMC. 2011 Mar-Jun 1
13 20676966 On the combined effect of statins and lycopene on cytokine production by human peripheral blood cells. 2010 Sep 1
14 19589242 Simvastatin reduces OX40 and OX40 ligand expression in human peripheral blood mononuclear cells and in patients with atherosclerotic cerebral infarction. 2009 May-Jun 1
15 19886038 Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. 2009 Aug 6
16 18453621 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 2008 May 15 1
17 18686224 Statins decrease the aberrant HLA-DR expression on thyrocytes from patients with Hashimoto's thyroiditis. 2008 Dec 1
18 18791454 Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells. 2008 Sep 15 1
19 16439692 Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. 2006 Mar 3 1
20 16621994 Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. 2006 May 1 1
21 16682645 Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. 2006 May 16 1
22 16870268 Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis. 2006 Sep 2
23 15936988 Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. 2005 Sep 3
24 11219190 The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. 2001 Jan 27 3
25 11397960 Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. 2001 May 15 5