Tetradecanoylphorbol Acetate

protein kinase C alpha ; Homo sapiens







386 Article(s)
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51 22921746 Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells. 2012 Sep 15 3
52 22988493 Reduced PKC α Activity Induces Senescent Phenotype in Erythrocytes. 2012 3
53 21062642 A role for protein kinase C in the regulation of membrane fluidity and Ca²(+) flux at the endoplasmic reticulum and plasma membranes of HEK293 and Jurkat cells. 2011 Feb 6
54 21354279 Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression. 2011 May 30 2
55 21375937 Mechanism governing reversal of multidrug resistance in human breast carcinoma cells by chelerythrine. 2011 Feb 2
56 21381080 Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells. 2011 Jul 4
57 21624785 Acute ethanol exposure prevents PMA-mediated augmentation of N-methyl-D-aspartate receptor function in primary cultured cerebellar granule cells. 2011 Sep 3
58 21705328 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. 2011 Aug 26 12
59 21842414 Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. 2011 Dec 4
60 21857090 Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level. 2011 1
61 21903576 Control of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12. 2011 Nov 4 1
62 22001118 Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins. 2011 Dec 10 1
63 22160590 Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. 2011 Dec 1
64 19887445 Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. 2010 Jan 8 2
65 20020096 Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. 2010 Apr 2
66 20032081 PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. 2010 May 1 1
67 20152819 Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms. 2010 Jun 15 1
68 20426528 Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha. 2010 May 4
69 20444294 PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells. 2010 May 6 2
70 20445555 PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents. 2010 Aug 2
71 20458747 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. 2010 Nov 6
72 20590612 Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. 2010 Jul 1
73 20669099 PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells. 2010 Jul 3
74 20673182 Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: the pivotal role of PKC-α translocation. 2010 Aug 2
75 20826143 Phorbol 12-myristate 13-acetate inhibits the antilipolytic action of insulin, probably via the activity of protein kinase Cε. 2010 Dec 1 3
76 19029835 PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. 2009 Jan 1
77 19343040 PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. 2009 Sep 2
78 19429793 Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. 2009 Aug 4
79 19586612 Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system. 2009 Nov 3
80 19755418 12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s). 2009 Oct 30 3
81 20011080 PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1. 2009 Dec 10 4
82 20177957 Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus. 2009 Oct 1
83 17654516 Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta. 2008 Feb 2
84 18056764 Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. 2008 May 1 2
85 18291120 Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells. 2008 Apr 15 1
86 18372343 Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites. 2008 Jun 2
87 18534741 Activation of PKC epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol ester. 2008 Jul 16 2
88 18541361 Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta. 2008 Sep 24 1
89 18594782 Endothelial PKC delta activation attenuates neutrophil transendothelial migration. 2008 May 2
90 18755856 Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity. 2008 Nov 2
91 18778746 The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. 2008 Dec 2
92 19077250 Protein kinase Cepsilon is important for migration of neuroblastoma cells. 2008 Dec 11 1
93 17091491 PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells. 2007 Jan 15 1
94 17171646 Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha. 2007 May 15 2
95 17200207 Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. 2007 Jan 2
96 17207890 Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells. 2007 May 4
97 17267550 Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells. 2007 May 1
98 17321112 Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. 2007 May 2
99 17325208 PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages. 2007 Feb 26 1
100 17334233 PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells. 2007 Feb 28 6