Diphosphonates

farnesyl diphosphate synthase ; Homo sapiens







109 Article(s)
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51 21247791 Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw. 2011 Mar 1
52 21335425 Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate. 2011 May 2
53 21420384 Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. 2011 Apr 22 2
54 21465521 Bisphosphonates, specific inhibitors of osteoclast function and a class of drugs for osteoporosis therapy. 2011 May 1
55 21497677 The relationship between the chemistry and biological activity of the bisphosphonates. 2011 Jul 2
56 21555003 Bisphosphonates: the first 40 years. 2011 Jul 4
57 21702715 Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). 2011 Sep 2
58 22091898 Bisphosphonates and osteonecrosis of the jaw. 2011 Dec 1
59 19819230 Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Mar 1 1
60 20191015 Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women. 2010 Mar 2
61 20299227 Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs). 2010 Apr 1 1
62 20450493 Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. 2010 Jul 15 1
63 20533067 Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget's disease. 2010 Nov 1
64 20539033 Bisphosphonate therapeutics in bone disease: the hard and soft data on osteoclast inhibition. 2010 Jun 1
65 20544107 Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway. 2010 Aug 7 2
66 20711197 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. 2010 Sep 2
67 20722616 Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. 2010 2
68 20801032 Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase. 2010 Oct 1 3
69 20832326 Synthesis and biological evaluation of a series of aromatic bisphosphonates. 2010 Oct 15 1
70 19016713 Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. 2009 Jan 1
71 19233551 Bisphosphonate zoledronic acid enhances the inhibitory effects of gefitinib on EGFR-mutated non-small cell lung carcinoma cells. 2009 Jun 8 1
72 19309137 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. 2009 Apr 15 2
73 19371349 Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro. 2009 Jun 1
74 19665949 Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 Oct 1 1
75 19699819 The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. 2009 Dec 2
76 19810397 Bisphosphonates and osteonecrosis of the jaw--current thoughts. 2009 Sep 1
77 18214569 Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. 2008 Jun 2
78 18327899 Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. 2008 Apr 10 1
79 18442135 Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. 2008 Nov 1 2
80 18454049 Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. 2008 Apr 1
81 18463892 Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders. 2008 Jul 1
82 18473904 Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. 2008 Mar 2
83 18800762 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. 2008 Sep 25 1
84 16996129 Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. 2007 Mar 1
85 17277961 [Introduction to bisphosphonates. History and functional mechanisms]. 2007 Feb 1
86 17291279 Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. 2007 Feb 1
87 17535895 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. 2007 Jun 12 2
88 17959891 Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates. 2007 Nov 1
89 18056045 Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. 2007 Nov 2
90 22460750 Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders. 2007 Jan 1
91 16216433 Minodronate, a nitrogen-containing bisphosphonate, is a promising remedy for treating patients with diabetic retinopathy. 2006 1
92 16650801 Recent advances in understanding the mechanism of action of bisphosphonates. 2006 Jun 1
93 16684881 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. 2006 May 16 2
94 16831938 Bisphosphonates: from bench to bedside. 2006 Apr 4
95 16892359 Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. 2006 Feb 4
96 16932286 Drug insight: Bisphosphonates for postmenopausal osteoporosis. 2006 Apr 1
97 16956297 Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation. 2006 Sep 14 2
98 17062705 Molecular mechanisms of action of bisphosphonates: current status. 2006 Oct 15 2
99 17090032 Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes. 2006 Nov 15 2
100 15828834 Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. 2005 Apr 21 2