| 1 |
34896359 | Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use. | 2022 Mar |
4 |
| 2 |
35456610 | Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs. | 2022 Apr 2 |
2 |
| 3 |
35600875 | The Role of Geranylgeraniol in Managing Bisphosphonate-Related Osteonecrosis of the Jaw. | 2022 |
1 |
| 4 |
33559705 | Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders. | 2021 Jun |
2 |
| 5 |
31785819 | Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. | 2020 Jan 15 |
7 |
| 6 |
32057422 | NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activity. | 2020 May |
2 |
| 7 |
32537808 | Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase. | 2020 Nov 2 |
1 |
| 8 |
30036888 | QSAR Models for Nitrogen Containing Monophosphonate and Bisphosphonate Derivatives as Human Farnesyl Pyrophosphate Synthase Inhibitors Based on Monte Carlo Method. | 2019 Mar |
1 |
| 9 |
31023104 | A patent review of bisphosphonates in treating bone disease. | 2019 May |
2 |
| 10 |
31699606 | Novel benzimidazole phosphonates as potential inhibitors of protein prenylation. | 2019 Dec 15 |
1 |
| 11 |
28723699 | Intraoperative bleeding in patients with osteogenesis imperfecta type III treated by Fassier-Duval femoral rodding: analysis of risk factors. | 2018 Jul |
1 |
| 12 |
29080272 | 3D-QSAR, molecular docking, and ONIOM studies on the structure-activity relationships and action mechanism of nitrogen-containing bisphosphonates. | 2018 Mar |
2 |
| 13 |
29276048 | Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site. | 2018 Feb 15 |
2 |
| 14 |
29683099 | Identifying Potential Therapeutics for Osteoporosis by Exploiting the Relationship between Mevalonate Pathway and Bone Metabolism. | 2018 |
1 |
| 15 |
30096489 | Bisphosphonates: Future perspective for neurological disorders. | 2018 Oct |
4 |
| 16 |
32002964 | Bisphosphonates: Future perspective for neurological disorders. | 2018 Sep |
4 |
| 17 |
28559264 | Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis. | 2017 Aug |
1 |
| 18 |
28631130 | New insights into human farnesyl pyrophosphate synthase inhibition by second-generation bisphosphonate drugs. | 2017 Jul |
1 |
| 19 |
26781029 | Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase. | 2016 |
1 |
| 20 |
26891809 | Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis. | 2016 |
2 |
| 21 |
27428767 | Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. | 2016 Aug 9 |
1 |
| 22 |
25630225 | Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. | 2015 Mar 1 |
2 |
| 23 |
25815158 | Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. | 2015 Mar 12 |
2 |
| 24 |
26314394 | Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase. | 2015 Sep 24 |
1 |
| 25 |
26381451 | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. | 2015 Nov |
3 |
| 26 |
26457482 | A General Strategy for Targeting Drugs to Bone. | 2015 Nov 23 |
2 |
| 27 |
24172032 | Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase. | 2014 |
9 |
| 28 |
24246954 | Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors. | 2014 Mar |
2 |
| 29 |
24369118 | Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. | 2014 Apr 4 |
1 |
| 30 |
24598749 | Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. | 2014 Mar |
3 |
| 31 |
24598914 | Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. | 2014 Mar |
1 |
| 32 |
24699741 | Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate. | 2014 Apr |
2 |
| 33 |
24911527 | Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. | 2014 Jul 10 |
2 |
| 34 |
25130632 | [Genetics and pharmacogenetics of osteoporosis]. | 2014 Jul-Aug |
1 |
| 35 |
25365870 | [Molecular mechanisms of action of bisphosphonates and strontium ranelate]. | 2014 |
1 |
| 36 |
22842101 | Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development. | 2013 Jan 25 |
1 |
| 37 |
23421555 | Farnesyl diphosphate synthase inhibitors from in silico screening. | 2013 Jun |
2 |
| 38 |
23533771 | Bisphosphonates and cancer: what opportunities from nanotechnology? | 2013 |
2 |
| 39 |
23610597 | Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. | 2013 Apr 11 |
1 |
| 40 |
23794630 | Essential requirements of zoledronate-induced cytokine and γδ T cell proliferative responses. | 2013 Aug 1 |
1 |
| 41 |
23919676 | Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase. | 2013 Sep 23 |
2 |
| 42 |
21151198 | Common allelic variants of the farnesyl diphosphate synthase gene influence the response of osteoporotic women to bisphosphonates. | 2012 Jun |
1 |
| 43 |
21864230 | The chemistry of bisphosphonates: from antiscaling agents to clinical therapeutics. | 2012 Feb |
1 |
| 44 |
22884353 | Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls. | 2012 Sep 15 |
3 |
| 45 |
23234314 | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. | 2012 Dec 12 |
3 |
| 46 |
21110804 | Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. | 2011 |
1 |
| 47 |
21111853 | Biochemical and molecular mechanisms of action of bisphosphonates. | 2011 Jul |
2 |
| 48 |
21145999 | Denosumab and bisphosphonates: different mechanisms of action and effects. | 2011 Apr 1 |
1 |
| 49 |
21196316 | Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw. | 2011 Jan 1 |
1 |
| 50 |
21237288 | Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. | 2011 Apr |
1 |