Hydrocortisone

cytochrome P450 family 21 subfamily A member 2 ; Homo sapiens







26 Article(s)
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1 30982438 Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia. 2020 Mar 1
2 32203088 Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders. 2020 May 1
3 32610579 Non-Classic Disorder of Adrenal Steroidogenesis and Clinical Dilemmas in 21-Hydroxylase Deficiency Combined with Backdoor Androgen Pathway. Mini-Review and Case Report. 2020 Jun 29 1
4 28893623 CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2. 2017 Nov 1
5 26514241 Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). 2016 2
6 26941069 The experience of women living with Congenital Adrenal Hyperplasia: impact of the condition and the care given. 2016 Jul 1
7 27789139 Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome. 2016 Dec 1 1
8 26374204 A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of premedrol. 2015 Sep 15 1
9 24466573 Effects of novel brominated flame retardants on steroidogenesis in primary porcine testicular cells. 2014 Jan 3 1
10 25210767 Common genetic variants of the human steroid 21-hydroxylase gene (CYP21A2) are related to differences in circulating hormone levels. 2014 1
11 23084589 Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells. 2013 Jan 1
12 22886582 Complement component 4 copy number variation and CYP21A2 genotype associations in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 2012 Dec 1
13 21094146 Steroid synthesis by primary human keratinocytes; implications for skin disease. 2011 Jan 7 1
14 21446712 Why human cytochrome P450c21 is a progesterone 21-hydroxylase. 2011 May 17 1
15 20423741 Novel intronic CYP21A2 mutation in a Japanese patient with classic salt-wasting steroid 21-hydroxylase deficiency. 2010 Nov 1
16 17400813 Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium. 2007 Apr 1
17 15128284 Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal. 2004 May 1
18 14513879 Steroid 21-hydroxylase (P450c21) naturally occurring mutants I172N, V281L and I236n/V237E/M239K exert a dominant negative effect on enzymatic activity when co-expressed with the wild-type protein. 2003 Sep 1
19 11250647 Bioavailability of oral hydrocortisone in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 2001 Apr 1
20 8989258 Synergistic effect of partially inactivating mutations in steroid 21-hydroxylase deficiency. 1997 Jan 1
21 9187661 A cluster of missense mutations at Arg356 of human steroid 21-hydroxylase may impair redox partner interaction. 1997 Jun 1
22 7479886 Gene conversions and unequal crossovers between CYP21 (steroid 21-hydroxylase gene) and CYP21P involve different mechanisms. 1995 Nov 7 2
23 1937474 Substitution of Ile-172 to Asn in the steroid 21-hydroxylase B (P450c21B) gene in a Finnish patient with the simple virilizing form of congenital adrenal hyperplasia. 1991 Oct 1
24 1979956 Defective, deleted or converted CYP21B gene and negative association with a rare restriction fragment length polymorphism allele of the factor B gene in congenital adrenal hyperplasia. 1990 Dec 1
25 2233746 Expression of human 21-hydroxylase (P450c21) in bacterial and mammalian cells: a system to characterize normal and mutant enzymes. 1990 Jun 1
26 2249999 Determination of functional effects of mutations in the steroid 21-hydroxylase gene (CYP21) using recombinant vaccinia virus. 1990 Dec 5 1