Lactic Acid

solute carrier family 16 member 1 ; Homo sapiens







249 Article(s)
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151 25123669 Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms. 2014 Dec 1
152 25241983 Functional characterization of intracellular pH regulators responsible for acid extrusion in human radial artery smooth muscle cells. 2014 Oct 31 1
153 25277190 Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells. 2014 Sep 15 1
154 25281618 Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. 2014 Dec 2
155 25320343 Monocarboxylate transporters 1 and 4: expression and regulation by PPARα in ovine ruminal epithelial cells. 2014 Dec 15 1
156 24013424 CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells. 2013 Oct 1 1
157 24094633 The role of myelin and oligodendrocytes in axonal energy metabolism. 2013 Dec 1
158 24265240 Monocarboxylic acid transport. 2013 Oct 1
159 24455478 Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy. 2013 1
160 21856423 Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. 2012 Jan 2
161 22012699 Effects of acute and chronic exercise on sarcolemmal MCT1 and MCT4 contents in human skeletal muscles: current status. 2012 Jan 1 1
162 22178238 Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. 2012 Feb 15 1
163 22184616 Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. 2012 Feb 15 9
164 22240841 Genetic variations of the MCT4 (SLC16A3) gene in the Chinese and Indian populations of Singapore. 2012 2
165 22360558 Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. 2012 1
166 22407107 Role of monocarboxylate transporters in human cancers: state of the art. 2012 Feb 1
167 22428047 Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 2012 4
168 22473315 Lactate-induced IL-8 pathway in endothelial cells--letter. 2012 Apr 1 1
169 22516692 Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women. 2012 Nov 3
170 22850421 Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. 2012 Oct 1 2
171 22895074 The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer. 2012 Nov 2
172 23082126 Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. 2012 4
173 23177990 The SLC16A family of monocarboxylate transporters (MCTs)--physiology and function in cellular metabolism, pH homeostasis, and fluid transport. 2012 3
174 21036377 MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses with myopathy. 2011 Dec 1
175 21081165 Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. 2011 Feb 2
176 21282642 Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II. 2011 Feb 15 1
177 21300765 Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. 2011 Apr 1 1
178 21558814 Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. 2011 Jun 1 1
179 21856924 Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. 2011 Oct 2
180 21930917 CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. 2011 Oct 4 3
181 22065843 Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. 2011 Nov 1
182 19850519 MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. 2010 Sep 3
183 19876643 Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. 2010 Feb 1
184 19905008 The involvement of intracellular calcium in the MCT-mediated uptake of lactic acid by HeLa cells. 2010 Feb 1 2
185 20021214 Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. 2010 Jan 1
186 20823576 Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways. 2010 3
187 21076380 Mechanism analysis of long-term graft survival by monocarboxylate transporter-1 inhibition. 2010 Dec 27 1
188 18778892 A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. 2009 Jan 8 1
189 19404741 Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2. 2009 Oct 1
190 19427019 miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1. 2009 Sep 1
191 19505879 CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. 2009 Oct 2
192 19604494 Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated, perfused mouse hearts. 2009 Aug 26 1
193 19604589 Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. 2009 Sep 1
194 19741037 Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs. 2009 Dec 2
195 19805739 Cell-cell and intracellular lactate shuttles. 2009 Dec 1 1
196 19826085 Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells. 2009 Oct 27 4
197 19881260 Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore. 2009 4
198 18379211 Mitochondrial lactate oxidation complex and an adaptive role for lactate production. 2008 Mar 3
199 18668440 The SLC16 monocaboxylate transporter family. 2008 Jul 2
200 18761711 Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins. 2008 Nov 2