Lactic Acid

solute carrier family 16 member 1 ; Homo sapiens







249 Article(s)
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51 32650130 Targeting lactate production and efflux in prostate cancer. 2020 Nov 1 1
52 32667776 Compromised Lactate Efflux Renders Vulnerability of Oligodendrocyte Precursor Cells to Metabolic Stresses. 2020 Sep 2 2
53 32703414 Identification of the HT-29 cell line as a model for investigating MCT1 transporters in sigmoid colon adenocarcinoma. 2020 Aug 20 1
54 32717355 Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy. 2020 Nov 1
55 32821126 Tumor-Derived Exosome-Educated Hepatic Stellate Cells Regulate Lactate Metabolism of Hypoxic Colorectal Tumor Cells via the IL-6/STAT3 Pathway to Confer Drug Resistance. 2020 1
56 32839325 Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. 2020 Sep 8 3
57 32942665 Transmembrane Facilitation of Lactate/H+ Instead of Lactic Acid Is Not a Question of Semantics but of Cell Viability. 2020 Sep 15 4
58 33178603 Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer. 2020 2
59 33256802 Loss of miR-192-5p initiates a hyperglycolysis and stemness positive feedback in hepatocellular carcinoma. 2020 Nov 30 1
60 33296645 HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. 2020 Dec 8 2
61 33614502 Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells. 2020 3
62 30550949 Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment. 2019 Mar 15 1
63 30790227 Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma. 2019 Jun 1
64 30923124 Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. 2019 May 10 1
65 31171526 The Tumor Metabolic Microenvironment: Lessons from Lactate. 2019 Jul 1 1
66 31209810 Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma. 2019 Jun 2
67 31297034 Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. 2019 1
68 31367191 Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition. 2019 3
69 31380330 A SLC16A1 Mutation in an Infant With Ketoacidosis and Neuroimaging Assessment: Expanding the Clinical Spectrum of MCT1 Deficiency. 2019 5
70 31532712 A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1. 2019 Aug 3
71 31797891 Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment. 2019 Dec 4 2
72 28846107 Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. 2018 Jan 4 2
73 29351758 Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells. 2018 Jan 19 2
74 29483215 MCT4 Expression Is a Potential Therapeutic Target in Colorectal Cancer with Peritoneal Carcinomatosis. 2018 Apr 1
75 29572438 Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. 2018 Mar 23 2
76 29695106 BSG and MCT1 Genetic Variants Influence Survival in Multiple Myeloma Patients. 2018 Apr 24 1
77 29809145 A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells. 2018 May 29 1
78 29913143 Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling. 2018 Sep 5 2
79 29985759 An unexpected world population variation of MCT1 polymorphism 1470T > A involved in lactate transport. 2018 Nov 3
80 30026847 MCT1 regulates aggressive and metabolic phenotypes in bladder cancer. 2018 3
81 30115664 Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. 2018 Nov 1
82 30115973 Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer. 2018 Aug 16 2
83 30125826 AMP-activated protein kinase negatively regulates heat treatment-induced lactate secretion in cultured boar sertoli cells. 2018 Nov 1
84 30177396 Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population. 2018 Oct 1
85 30189359 AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. 2018 Oct 1
86 30355947 miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism. 2018 2
87 30464343 Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 2018 Nov 2
88 30540938 Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. 2018 Dec 11 3
89 27751602 Heat stress-induced autophagy promotes lactate secretion in cultured immature boar Sertoli cells by inhibiting apoptosis and driving SLC2A3, LDHA, and SLC16A1 expression. 2017 Jan 1 1
90 27813046 The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance. 2017 Jan 1
91 27957817 Monocarboxylate Transporter-1 Mediates the Protective Effects of Neutral-pH Bicarbonate/Lactate-Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis. 2017 Feb 2
92 28107190 Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. 2017 Apr 11 4
93 28148492 Rest interval duration does not influence adaptations in acid/base transport proteins following 10 wk of sprint-interval training in active women. 2017 May 1 1
94 28392448 Effect of nitric oxide to axonal degeneration in multiple sclerosis via downregulating monocarboxylate transporter 1 in oligodendrocytes. 2017 Jul 1 5
95 28421181 MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer. 2017 2
96 28536031 Lactate induces osteoblast differentiation by stabilization of HIF1α. 2017 Sep 5 1
97 28762551 Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk. 2017 Dec 1
98 28827372 Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter. 2017 Oct 15 3
99 28866133 MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases. 2017 Dec 4
100 28923861 MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy. 2017 Nov 1 1