epoxyeicosatrienoic acids

epoxide hydrolase 2 ; Rattus norvegicus







40 Article(s)
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1 35344709 Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats. 2022 May 28 3
2 32767848 Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. 2021 Jan 2
3 34794001 Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. 2021 Dec 1 1
4 32736189 Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. 2020 Oct 2
5 33475089 Inhibition of soluble epoxide hydrolase offers protection against fructose-induced diabetes and related metabolic complications in rats. 2020 Oct 1
6 30644034 TPPU, a sEH Inhibitor, Attenuates Corticosterone-Induced PC12 Cell Injury by Modulation of BDNF-TrkB Pathway. 2019 Mar 1
7 30728778 Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats. 2019 2
8 29527914 Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula. 2018 Jul 17 2
9 29529602 Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. 2018 2
10 28002622 Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. 2017 Mar 2
11 28332266 11,12-Epoxyeicosatrienoic acid induces vasodilator response in the rat perfused mesenteric vasculature. 2017 Jan 2
12 28707660 [Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension]. 2017 May-Jun 1
13 28741242 The weakening effect of soluble epoxide hydrolase inhibitor AUDA on febrile response to lipopolysaccharide and turpentine in rat. 2017 Nov 2
14 25663200 Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury. 2016 Apr 2
15 26545915 Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia. 2016 Feb 2
16 25986738 Soluble epoxide hydrolase inhibition ameliorates proteinuria-induced epithelial-mesenchymal transition by regulating the PI3K-Akt-GSK-3β signaling pathway. 2015 Jul 17-24 2
17 24471737 Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. 2014 Mar 2
18 25224811 Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. 2014 Dec 2
19 23039246 Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system. 2013 Apr 2
20 23232840 Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. 2013 Apr 2
21 23725831 Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. 2013 May 2
22 24043255 Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. 2013 Dec 1 2
23 22155000 A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. 2012 Feb 2
24 22155238 Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure. 2012 Mar 2
25 23106500 Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. 2012 2
26 21039415 Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury. 2011 Feb 2
27 21266668 Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. 2011 Apr 3
28 19847158 Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions. 2010 Jan 3
29 19969453 Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. 2010 Jan 15 1
30 19126686 Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. 2009 Jan 13 2
31 19226702 Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. 2009 Feb 2
32 19285984 Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells. 2009 Jun 2
33 19304946 Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. 2009 May 2
34 19746975 Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. 2009 Oct 8 2
35 18086949 Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. 2008 Feb 2
36 18443590 Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. 2008 May 1
37 17639071 A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat. 2007 Jul 2
38 16157792 An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. 2005 Oct 2
39 11090543 Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. 2000 Nov 24 1
40 7840649 Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. 1995 Jan 10 1