O-(6)-methylguanine

O-6-methylguanine-DNA methyltransferase ; Mus musculus







19 Article(s)
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1 31841318 Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. 2020 Feb 17 1
2 30446773 Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo. 2019 Feb 4
3 29632181 PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. 2018 Apr 24 1
4 26243310 DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. 2015 Oct 1
5 24519900 Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice. 2014 Mar 1
6 21493591 Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid. 2011 Jun 15 1
7 19124772 O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. 2009 Jan 13 3
8 12663516 DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors. 2003 Mar 1
9 11795504 Health span and life span in transgenic mice with modulated DNA repair. 2001 Apr 1
10 10814890 Formation and persistence of O(6)-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O(6)-alkylguanine-DNA alkyltransferase inactivation assay. 2000 Jun 5 2
11 10391687 Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. 1999 Jun 24 1
12 9609323 O6-methylguanine and O6-methylguanine-DNA [corrected] methyltransferase activity in tissues of BDF-1 mice treated with antiparasitic drugs. 1998 Feb 6
13 9931384 Repair of DNA lesion O6-methylguanine in hepatocellular carcinogenesis. 1998 2
14 9163672 Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting. 1997 May 1
15 9366529 Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase. 1997 Oct 23 1
16 8062258 Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. 1994 Sep 1 2
17 2054779 Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene. 1991 Jul 1 2
18 2557168 Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine. 1989 5
19 3698207 Cell cycle-dependent modulation of O6-methylguanine-DNA methyltransferase in C3H/10T1/2 cells. 1986 May 1