O(6)-benzylguanine

⇄

O-6-methylguanine-DNA methyltransferase ; Mus musculus







24 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 32510630 In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy. 2021 Jan 1
2 32457126 Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma. 2020 May 4
3 30274152 Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo. 2018 Sep 28 3
4 23479134 Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models. 2013 Jun 3
5 18076130 Co-expression of MGMT(P140K) and alpha-L-iduronidase in primary hepatocytes from mucopolysaccharidosis type I mice enables efficient selection with metabolic correction. 2008 Mar 2
6 17875772 Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. 2007 Sep 15 2
7 16927363 Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow. 2006 Sep 2
8 15010311 Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. 2004 Apr 1 2
9 15284838 Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. 2004 Nov 1
10 15308322 Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. 2004 Aug 7
11 12842427 Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. 2003 Jul 2
12 14506174 Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. 2003 Sep 1 3
13 14707273 Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea. 2003 Dec 1
14 12189523 Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells. 2002 Sep 7
15 10647505 Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism. 2000 7
16 10770631 Enhancing hemopoietic drug resistance: a rationale for reconsidering the clinical use of mitozolomide. 2000 Feb 1
17 10807772 Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. 2000 May 15 1
18 10864847 Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents. 2000 Jul 2
19 11016647 Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. 2000 Sep 15 1
20 10188873 Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice. 1999 Mar 4
21 10454526 Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment. 1999 Sep 1
22 10590234 O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes. 1999 Dec 2
23 7923129 Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. 1994 Oct 1 3
24 2242301 Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. 1990 2