| 1 |
32035014 | Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects. | 2020 Jul |
2 |
| 2 |
31288895 | A new similarity method for assessment of pharmacokinetic interaction between flucloxacillin and midazolam. | 2019 Jul 1 |
1 |
| 3 |
31474719 | The Prediction of the Area under the Curve and Clearance of Midazolam from Single-Point Plasma Concentration and Urinary Excretion in Healthy Volunteers. | 2019 |
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| 4 |
29352982 | Inhibition of CYP3A by Antimalarial Piperaquine and Its Metabolites in Human Liver Microsomes With IVIV Extrapolation. | 2018 May |
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| 5 |
26123704 | Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. | 2016 Jan |
1 |
| 6 |
27876007 | Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery. | 2016 Nov 23 |
1 |
| 7 |
22777148 | Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. | 2013 Mar |
2 |
| 8 |
23674377 | Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures. | 2013 Sep |
2 |
| 9 |
23682612 | The effect of organic solvents on enzyme kinetic parameters of human CYP3A4 and CYP1A2 in vitro. | 2013 Oct |
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| 10 |
21993197 | Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection. | 2012 Jan 25 |
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| 11 |
22022919 | Microbial production of phase I and phase II metabolites of midazolam. | 2012 Mar |
1 |
| 12 |
22415932 | Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro. | 2012 Jun |
3 |
| 13 |
21111054 | Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. | 2011 May-Jun |
1 |
| 14 |
21447734 | Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction. | 2011 Jul |
1 |
| 15 |
21513075 | Influence of CYP3A5*3 polymorphism and interaction between CYP3A5*3 and CYP3A4*1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery. | 2011 Apr |
1 |
| 16 |
19784640 | CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients. | 2010 Jan |
1 |
| 17 |
20680253 | Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam. | 2010 Nov |
1 |
| 18 |
21042038 | In vitro and in vivo inhibitory effects of glycyrrhetinic acid on cytochrome P450 3A activity. | 2010 |
1 |
| 19 |
19571438 | Different enzyme kinetics of midazolam in recombinant CYP3A4 microsomes from human and insect sources. | 2009 |
1 |
| 20 |
19701237 | Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism. | 2009 Sep |
1 |
| 21 |
18191104 | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 Mar 15 |
1 |
| 22 |
18242899 | Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. | 2008 May 22 |
2 |
| 23 |
18332086 | Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. | 2008 Jun |
1 |
| 24 |
17495418 | Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate. | 2007 Apr |
1 |
| 25 |
17521300 | Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. | 2007 Jun |
1 |
| 26 |
17117443 | Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes. | 2006 |
1 |
| 27 |
15735612 | Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression. | 2005 Mar |
1 |
| 28 |
15801939 | Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein. | 2005 Apr |
1 |
| 29 |
15845749 | Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. | 2005 Jul |
1 |
| 30 |
15058585 | Determination of midazolam and its metabolite as a probe for cytochrome P450 3A4 phenotype by liquid chromatography-mass spectrometry. | 2004 Mar 26 |
1 |
| 31 |
15289787 | Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states. | 2004 Aug |
1 |
| 32 |
12630976 | The distribution and gender difference of CYP3A activity in Chinese subjects. | 2003 Mar |
3 |
| 33 |
12695342 | Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. | 2003 May |
1 |
| 34 |
12937874 | Relationship between CYP3A activity and breast cancer susceptibility in Chinese Han women. | 2003 Sep |
2 |
| 35 |
12124305 | Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. | 2002 Aug |
1 |
| 36 |
11573629 | Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies. | 2001 Apr |
1 |
| 37 |
10741627 | Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe. | 2000 Mar |
1 |
| 38 |
10997946 | Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems. | 2000 Oct |
2 |
| 39 |
9531525 | Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. | 1998 Apr |
1 |
| 40 |
9145912 | Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. | 1997 May |
1 |
| 41 |
8646820 | Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. | 1996 May |
1 |
| 42 |
8669558 | What changes drug metabolism in critically ill patients?--II Serum inhibits the metabolism of midazolam in human microsomes. | 1996 Jan |
1 |
| 43 |
8689807 | First-pass metabolism of midazolam by the human intestine. | 1996 Jul |
1 |
| 44 |
8700118 | Bimodal distribution of renal cytochrome P450 3A activity in humans. | 1996 Jul |
2 |
| 45 |
8866916 | In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A. | 1996 Mar |
1 |
| 46 |
8531073 | Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro. | 1995 Dec |
3 |
| 47 |
7937537 | Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. | 1994 Jun |
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| 48 |
7965755 | Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients. | 1994 Oct |
1 |
| 49 |
8185679 | Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. | 1994 Apr 29 |
3 |