Dexamethasone

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cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







91 Article(s)
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51 15133628 Dexamethasone as a probe for docetaxel clearance. 2004 Sep 1
52 12538830 Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. 2003 Feb 2
53 12679136 Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43. 2003 Apr 11 1
54 12781341 In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. 2003 Jun 1 3
55 12843151 Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test. 2003 Jul 1
56 12065440 The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. 2002 Jul 5
57 12167569 Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. 2002 Sep 1
58 12369894 Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. 2002 Oct 1
59 11231298 Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. 2001 Mar 1
60 11336975 Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. 2001 May 16 2
61 11560876 Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. 2001 Oct 1
62 11602520 Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor. 2001 Nov 1
63 11737189 Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. 2001 Dec 5
64 10752642 Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. 2000 Mar 1
65 10772626 Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. 2000 May 1
66 10828267 Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. 2000 Jun 1
67 10908304 Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. 2000 Aug 4
68 10923861 Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up. 2000 Jun 1
69 10999732 Optimizing the erythromycin breath test for use in cancer patients. 2000 Sep 1
70 11061575 In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. 2000 Oct 10
71 11093784 Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. 2000 Dec 1
72 11103751 The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect. 2000 Nov 2
73 10219967 A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. 1999 Mar 1
74 10548883 The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. 1999 1
75 9468221 Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene. 1998 Jan 1
76 9536002 Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. 1998 Apr 1
77 9661620 Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. 1998 Jul 2
78 9783333 The effect of dexamethasone on the pharmacokinetics of triazolam. 1998 Sep 3
79 9806224 Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats. 1998 1
80 9826540 Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals. 1998 Nov 18 1
81 9337077 In vitro metabolism of dexamethasone (DEX) in human liver and kidney: the involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies. 1997 Sep 1 2
82 9408089 Dexamethasone metabolism in vitro: species differences. 1997 Jul 3
83 8569713 Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. 1996 Jan 1
84 8613906 Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. 1996 Apr 1
85 8619627 Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. 1996 May 1 1
86 8640817 Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans. 1996 Mar 15 1
87 8643461 Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. 1996 May 14 2
88 8700101 Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. 1996 Jul 1
89 7628309 Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. 1995 Mar 2
90 8003039 Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein. 1994 Jun 15 1
91 8114683 O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. 1994 Feb 1