Simvastatin

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







123 Article(s)
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51 22451032 Interleukin-6 and cytochrome-P450, reason for concern? 2012 Sep 1
52 22529023 Statin medication in patients treated with antiepileptic drugs in Norway. 2012 Aug 1
53 22912565 Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. 2012 1
54 23032911 Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity. 2012 2
55 21443601 Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A. 2011 Apr 1
56 21844990 Tacrolimus and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: An interaction study in CYP3A5 non-expressors, renal transplant recipients. 2011 Jul 1
57 21883349 Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma. 2011 Nov 1
58 21946898 Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. 2011 Dec 8
59 22287853 Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole. 2011 1
60 19802823 Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. 2010 Jan 4
61 19943026 [Interactions with antiretroviral drugs]. 2010 Jan 1
62 20150526 Effects of concomitant therapy with diltiazem on the lipid responses to simvastatin in Chinese subjects. 2010 Oct 1
63 20203109 Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. 2010 Jun 2
64 20829626 Management of dyslipidemia in Cushing's syndrome. 2010 2
65 21045169 Rhabdomyolysis in a patient receiving high-dose simvastatin after the induction of therapeutic hypothermia. 2010 Dec 1
66 21105332 [Effect of polymorphisms of cytochrome P450 and apolipoprotein E genes on therapeutic efficacy of statins]. 2010 1
67 19206087 Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors. 2009 Apr 2
68 19220274 Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy. 2009 Feb 3
69 19429419 Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells. 2009 May 12 1
70 20183988 [Statins under fire: justified or not?]. 2009 Dec 1
71 18213452 Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. 2008 Jul 2
72 18302447 Frequency and clinical relevance of drug interactions with lovastatin and simvastatin: an observational database study. 2008 2
73 18558792 Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors. 2008 4
74 18783297 General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. 2008 1
75 17192506 Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects. 2007 Jan 1
76 17304269 [Interaction risk with statin switch]. 2007 Feb 15 2
77 17381388 Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. 2007 Apr 2
78 17615423 Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. 2007 Jul-Aug 2
79 18220561 Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis. 2007 Dec 1
80 16415122 In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer. 2006 Apr 1
81 16537817 Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity. 2006 Apr 2
82 16580903 Comparison of midazolam and simvastatin as cytochrome P450 3A probes. 2006 Apr 2
83 16581325 Statin safety and drug interactions: clinical implications. 2006 Apr 17 2
84 16581329 Statin safety: a systematic review. 2006 Apr 17 4
85 16611111 Thienopyridines and statins: assessing a potential drug-drug interaction. 2006 1
86 16714062 Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. 2006 Oct 2
87 17178259 Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. 2006 Dec 2
88 15650881 Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients. 2005 Feb 5
89 15679472 Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence. 2005 Feb 1
90 15811174 Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis. 2005 Apr 1
91 15963098 Suboptimal choices and dosing of statins at start of therapy. 2005 Jul 1
92 16238904 Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections. 2005 Oct 1
93 16264203 Myonecrosis after elective percutaneous coronary intervention: effect of clopidogrel-statin interaction. 2005 Nov 1
94 16321621 The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. 2005 Nov 1
95 12603176 Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin. 2003 1
96 12817528 Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. 2003 Jun 1
97 14522569 Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study. 2003 Oct 1
98 14612892 Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. 2003 Nov 17 2
99 12410059 Colchicine-induced acute myopathy in a patient with concomitant use of simvastatin. 2002 Sep-Oct 1
100 12433810 Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. 2002 Dec 1