testosterone 6beta

⇄

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







48 Article(s)
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1 33790108 Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies. 2021 1
2 31102695 Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity. 2019 Jul 1 1
3 27934636 Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor. 2017 Feb 3
4 25678418 Regioselective hydroxylation of steroid hormones by human cytochromes P450. 2015 May 1
5 26239802 Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. 2015 Oct 1 1
6 24078287 Regulation of cytochrome b5 expression by miR-223 in human liver: effects on cytochrome P450 activities. 2014 Mar 1
7 24256945 Two surfaces of cytochrome b5 with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries. 2014 Jan 1 1
8 23514827 Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. 2013 1
9 22022918 Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5. 2012 Mar 1
10 22382318 Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. 2012 1
11 22509825 Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist. 2012 Oct 1
12 20955791 Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. 2011 Jan 18 1
13 21273732 Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. 2011 Jun 1
14 21964476 Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells. 2011 Dec 1
15 20964620 Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes. 2010 Dec 2
16 19817686 Electron transfer properties and catalytic competence of cytochrome b5 in the fusion protein Hmwb5-EGFP in reactions catalyzed by cytochrome P450 3A4. 2009 Aug 1
17 17827338 Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. 2007 Dec 1
18 16344723 Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations. 2006 Jan 2
19 16416302 Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. 2006 Mar 1
20 16702113 Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns. 2006 Feb-Mar 1
21 16719384 Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation. 2006 2
22 27699667 Thin-Layer Chromatography Analysis of Human CYP3A-Catalyzed Testosterone 6β-Hydroxylation. 2006 2
23 15608130 Development and validation of a high-throughput radiometric CYP3A4/5 inhibition assay using tritiated testosterone. 2005 Mar 1
24 15763633 Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion. 2005 Apr 28 1
25 15772082 Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps. 2005 May 20 1
26 15792627 Effects of nonylphenol on hepatic testosterone metabolism and the expression of acute phase proteins in winter flounder (Pleuronectes americanus): comparison to the effects of Saint John's Wort. 2005 Jan 1
27 15175893 Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes. 2004 Sep 1
28 12756208 Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. 2003 Jun 1
29 14690448 Membrane properties induced by anionic phospholipids and phosphatidylethanolamine are critical for the membrane binding and catalytic activity of human cytochrome P450 3A4. 2003 Dec 30 1
30 12185560 Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression. 2002 Aug 1
31 12419016 Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. 2002 Oct 1
32 11353747 A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine. 2001 Jun 1
33 11717174 Characterization of the selectivity and mechanism of cytochrome P450 inhibition by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate. 2001 Dec 2
34 10668853 CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. 2000 Jan 2
35 10771285 Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. 2000 Apr 14 1
36 10859150 Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. 2000 Jul 1
37 10950859 CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes. 2000 Sep 1
38 11523064 Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. 2000 Dec 1
39 10216279 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. 1999 Apr 19 1
40 10421615 The use of human hepatocyte cultures to study the induction of cytochrome P-450. 1999 Aug 1
41 10460798 Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. 1999 Sep 1
42 10525096 Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. 1999 Nov 2
43 9491822 Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. 1998 Feb 1
44 9698298 Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4. 1998 Aug 1
45 9806945 Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. 1998 Nov 2
46 9223567 Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. 1997 Jul 1
47 9278209 Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. 1997 Aug 1
48 8820421 Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. 1996 Mar 2