Mibefradil

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







15 Article(s)
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1 32331852 Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study. 2020 Jun 1
2 31480231 Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6',7'-Dihydroxybergamottin. 2019 Aug 30 2
3 21447734 Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction. 2011 Jul 6
4 24479199 ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4 2010 2
5 18411403 The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. 2008 Jul 2
6 18473851 Potential strategies for minimizing mechanism-based inhibition of cytochrome P450 3A4. 2008 1
7 17392390 Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. 2007 Jul 1
8 15860655 Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. 2005 Aug 1
9 10640508 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. 2000 Feb 2
10 10901697 Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. 2000 Aug 5
11 10215754 Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations. 1999 Mar 8
12 10226769 Mibefradil, a potent CYP3A inhibitor, does not alter pravastatin pharmacokinetics. 1999 1
13 10546924 Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. 1999 Oct 3
14 9681729 Pharmacokinetic interaction between oral cyclosporin and mibefradil in stabilized post-renal-transplant patients. 1998 Jul 1
15 9811158 Single- and multiple-dose mibefradil pharmacokinetics in normal and hypertensive subjects. 1998 Sep 2