Cyclosporine

⇄

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







192 Article(s)
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Title
Pub. Year
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101 16759707 An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. 2006 Oct 1
102 16911928 Genetic factors for individual administration of immunosuppressants in organ transplantation. 2006 Aug 1
103 17042920 Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation. 2006 Nov 2
104 17178259 Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. 2006 Dec 2
105 15723604 Cytochrome P450 3A polymorphisms and immunosuppressive drugs. 2005 Jan 1
106 15845749 Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. 2005 Jul 3
107 16027407 Concomitant cyclosporine and micafungin pharmacokinetics in healthy volunteers. 2005 Aug 1
108 16095503 Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus. 2005 Sep 1
109 16198658 Cyclosporine markedly raises the plasma concentrations of repaglinide. 2005 Oct 1
110 16205037 [Drug-drug interaction of antifungal drugs]. 2005 Oct 1
111 16298597 No gender-associated differences of cyclosporine pharmacokinetics in stable renal transplant patients treated with diltiazem. 2005 Oct 1
112 16541750 [Incremental effect and mechanism of cyclosporine on blood concentration of statins and statin package insert information in Japan]. 2005 3
113 14617681 Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. 2004 Mar 1
114 15116055 CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation. 2004 May 2
115 15197524 Gene expression of cytochromes P450 in liver transplants over time. 2004 Aug 3
116 15307840 CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. 2004 Sep 5
117 15350151 Drug interactions with St John's wort : mechanisms and clinical implications. 2004 1
118 15369802 Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4. 2004 Oct 15 1
119 15450954 In vitro metabolism of cyclosporine A by human kidney CYP3A5. 2004 Nov 1 4
120 15454731 The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients. 2004 Oct 2
121 15592326 Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes. 2004 Dec 3
122 12558459 Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients. 2003 1
123 12562644 Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer. 2003 Feb 2
124 12563178 Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. 2003 Feb 2
125 12673034 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. 2003 Apr 6
126 12766558 Association of the CYP3A4*1B 5'-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects. 2003 Jun 1
127 12817518 The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients. 2003 Jun 4
128 12966368 Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. 2003 Sep 2
129 11849198 St Johns wort increases expression of P-glycoprotein: implications for drug interactions. 2002 Jan 1
130 11888457 St John's Wort supplements endanger the success of organ transplantation. 2002 Mar 1
131 11914905 Effects of paclitaxel, cyclophosphamide, ifosfamide, tamoxifen and cyclosporine on the metabolism of methoxymorpholinodoxorubicin in human liver microsomes. 2002 Apr 1
132 11978159 Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole. 2002 May 1
133 12036392 Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. 2002 1
134 12160480 Pharmacokinetic interactions between herbal remedies and medicinal drugs. 2002 Jun 1
135 12497749 [Interaction between sildenafil and calcineurin inhibitors in renal transplant recipients with erectile dysfunction]. 2002 1
136 12523495 Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. 2002 Jul-Aug 1
137 12698985 Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. 2002 Nov 1
138 11181682 Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel. 2001 Feb 15 2
139 11239516 Preliminary report on the effect of xenoperfusion with human blood on cyclosporin A metabolism and cytochrome-P-4503A4-mRNA expression in a pig liver perfusion model. 2001 Feb 2
140 11375290 No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. 2001 Jun 2
141 11408558 P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4. 2001 Jul 1
142 11549208 Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel. 2001 Jul 2
143 11719731 Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients. 2001 Nov 4
144 11836874 [Safety profile of statins]. 2001 Nov 1
145 11871046 St John's wort: a hidden risk for transplant patients. 2001 Jun 1
146 10668858 Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. 2000 Jan 1
147 10741627 Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe. 2000 Mar 7
148 10752642 Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. 2000 Mar 1
149 10786743 The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro. 2000 May 1
150 10898107 Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. 2000 Jul 2