Cyclosporine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







192 Article(s)
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51 25561870 Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin. 2014 Dec 1
52 22886152 ABCB1 polymorphisms are associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients. 2013 Mar 1
53 23252948 CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy. 2013 Jan 4
54 23557867 CYP3A4/5 polymorphisms affect the blood level of cyclosporine and tacrolimus in Chinese renal transplant recipients. 2013 Jun 3
55 23841924 [Low cyclosporin levels induced by the brief use of rifampicin; immunosuppression may fail for several weeks]. 2013 1
56 22205779 Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. 2012 Apr 5
57 22388796 The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients. 2012 May 2
58 22476221 Hepatitis C virus treatment and liver transplantation in the era of new antiviral therapies. 2012 Jun 1
59 22576324 Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers. 2012 Nov 1
60 23018254 Impact of CYP3A4*1B and CYP3A5*3 polymorphisms on the pharmacokinetics of cyclosporine and sirolimus in renal transplant recipients. 2012 Jul-Sep 6
61 23085740 Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post-renal transplant recipients in China. 2012 Dec 3
62 23217392 CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal transplant recipients. 2012 Dec 6
63 21349923 Seasonal variation in blood drug concentrations and a potential relationship to vitamin D. 2011 May 1
64 21466223 Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. 2011 May 11 5
65 21480191 Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors. 2011 Aug 1
66 21753749 In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients. 2011 Sep 6
67 21857093 Influence of ABCB1, CYP3A4*18B and CYP3A5*3 polymorphisms on cyclosporine A pharmacokinetics in bone marrow transplant recipients. 2011 2
68 21902502 Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients. 2011 Oct 3
69 22016125 [Drug interactions and immunosuppression in organ transplant recipients]. 2011 Oct 18 1
70 19823813 Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2? 2010 Feb 1
71 20170205 Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I. 2010 Mar 1
72 20416375 The PXR is a drug target for chronic inflammatory liver disease. 2010 May 31 1
73 20599501 Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells. 2010 Oct 9 1
74 19183931 [Drug-drug interactions in urology]. 2009 Mar 1
75 19343062 Effect of bifendate on the pharmacokinetics of cyclosporine in relation to the CYP3A4*18B genotype in healthy subjects. 2009 Apr 6
76 19667964 Pharmacogenetics of calcineurin inhibitors in renal transplantation. 2009 Aug 15 1
77 19728747 Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions. 2009 1
78 19729463 Incidence, predictors and associated outcomes of rhabdomyolysis after kidney transplantation. 2009 Dec 1
79 20038391 [Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients]. 2009 Nov-Dec 1
80 18076219 Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects. 2008 1
81 18192894 Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms. 2008 Feb 1
82 18223473 Everolimus exposure in cardiac transplant recipients is influenced by concomitant calcineurin inhibitor. 2008 Feb 1
83 18518855 A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. 2008 Jun 1
84 18608282 Colchicine-induced toxicity in a heart transplant patient with chronic renal failure. 2008 Nov 2
85 18636247 Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients. 2008 Nov 2
86 18665658 Secondary prevention of coronary heart disease in elderly patients following myocardial infarction: are all HMG-CoA reductase inhibitors alike? 2008 1
87 18721002 Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. 2008 1
88 18978522 CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. 2008 Dec 6
89 19005401 Haplotypic structure of ABCB1/MDR1 gene modifies the risk of the acute allograft rejection in renal transplant recipients. 2008 Nov 15 1
90 17151193 Metabolism of sirolimus in the presence or absence of cyclosporine by genotyped human liver microsomes and recombinant cytochromes P450 3A4 and 3A5. 2007 Mar 1
91 17202802 Effect of cyclosporine and tacrolimus on cytochrome p450 activities in human liver microsomes. 2007 Jan 1
92 17244767 Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin (MK-0431), a dipeptidyl peptidase-4 inhibitor, in healthy male subjects. 2007 Feb 1
93 17374625 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? 2007 Apr 1
94 17425754 Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements. 2007 Mar-Apr 1
95 17545536 A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871. 2007 Jun 1 1
96 17624028 Association of CYP3A4*18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects. 2007 Mar 3
97 18240909 Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update. 2007 Jul 1
98 16611021 Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. 2006 Apr 2
99 16612333 The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients. 2006 May 3
100 16634729 Withdrawal symptoms from transdermal fentanyl (TDF) after an allogeneic peripheral blood stem cell transplant (PBSCT). 2006 Mar-Apr 1