| 1 |
35428895 | Assessment of cytochrome P450 3A4-mediated drug-drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model. | 2022 May |
1 |
| 2 |
32813881 | Drug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction. | 2021 Apr |
1 |
| 3 |
33217171 | Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling. | 2021 Jan |
1 |
| 4 |
33452585 | Population pharmacokinetic modelling to quantify the magnitude of drug-drug interactions between amlodipine and antiretroviral drugs. | 2021 Jul |
1 |
| 5 |
34495458 | Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making. | 2021 Nov |
1 |
| 6 |
31628422 | Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers. | 2020 Apr |
1 |
| 7 |
29098603 | Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers. | 2018 Apr |
1 |
| 8 |
29191071 | Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding. | 2018 Dec |
1 |
| 9 |
27599706 | Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes. | 2017 Apr |
2 |
| 10 |
27872069 | Evaluation of Doravirine Pharmacokinetics When Switching from Efavirenz to Doravirine in Healthy Subjects. | 2017 Feb |
1 |
| 11 |
28194792 | Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz. | 2017 Jul |
1 |
| 12 |
25733917 | The role of dolutegravir in the management of HIV infection. | 2015 |
1 |
| 13 |
26288843 | Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis. | 2015 Jul |
2 |
| 14 |
24474568 | A phase 1/pharmacokinetic study of sunitinib in combination with highly active antiretroviral therapy in human immunodeficiency virus-positive patients with cancer: AIDS Malignancy Consortium trial AMC 061. | 2014 Apr 15 |
1 |
| 15 |
24488374 | Combination antiretroviral therapy (cART) component ritonavir significantly alters docetaxel exposure. | 2014 Apr |
1 |
| 16 |
24846165 | Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib--a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer. | 2014 Nov |
1 |
| 17 |
25096076 | Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment. | 2014 Dec |
3 |
| 18 |
22642697 | The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers. | 2013 Feb |
1 |
| 19 |
23385314 | In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19. | 2013 |
1 |
| 20 |
23583259 | Agonism of human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase inhibitors. | 2013 Jun 1 |
2 |
| 21 |
25505649 | Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz. | 2013 |
1 |
| 22 |
22398970 | Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. | 2012 Apr |
1 |
| 23 |
22415932 | Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro. | 2012 Jun |
3 |
| 24 |
22918158 | Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. | 2012 Nov 1 |
1 |
| 25 |
21080015 | A computational study of CYP3A4 mediated drug interaction profiles for anti-HIV drugs. | 2011 Aug |
3 |
| 26 |
20201776 | Impact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes. | 2010 Jan |
7 |
| 27 |
20699409 | A 96-well plate assay for CYP4503A induction using cryopreserved human hepatocytes. | 2010 Nov |
1 |
| 28 |
20861742 | Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans. | 2010 Dec 15 |
1 |
| 29 |
18332078 | Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. | 2008 Jun |
1 |
| 30 |
18333864 | Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. | 2008 Apr |
2 |
| 31 |
18458892 | CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels. | 2008 Aug |
2 |
| 32 |
18783297 | General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. | 2008 |
1 |
| 33 |
15657782 | Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients. | 2005 Feb |
3 |
| 34 |
15980690 | Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study. | 2005 Jul 1 |
2 |
| 35 |
16267764 | Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. | 2005 Dec 1 |
1 |
| 36 |
15496645 | Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. | 2004 Nov |
3 |
| 37 |
12151999 | Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans. | 2002 Jul |
2 |
| 38 |
12405865 | Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. | 2002 |
1 |
| 39 |
10082072 | Drug interactions of HIV protease inhibitors. | 1999 Feb |
1 |
| 40 |
10622035 | Clinical history of efavirenz. | 1999 Jun |
1 |