Clopidogrel

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







83 Article(s)
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51 20942779 Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability. 2010 Oct 1
52 21073556 Antiplatelet drug interactions. 2010 Dec 1
53 21084035 Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin. 2010 Dec 2
54 19067731 The genetics of antiplatelet drug resistance. 2009 Jan 1
55 19246723 Clopidogrel resistance: pharmacokinetic or pharmacogenetic? 2009 May 1
56 19253920 Investigation of an interaction between statins and clopidogrel after percutaneous coronary intervention: a cohort study. 2009 May 3
57 19337788 Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome. 2009 Mar 2
58 19531897 Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan. 2009 Aug 2
59 18385991 Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects. 2008 Jun 2
60 18440347 High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients--a Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis. 2008 May 1
61 18474675 Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. 2008 Aug 1
62 19007592 Calcium-channel blockers reduce the antiplatelet effect of clopidogrel. 2008 Nov 4 2
63 19544679 Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4. 2008 1
64 17261397 Effect of atorvastatin and pravastatin on platelet inhibition by aspirin and clopidogrel treatment in patients with coronary stent thrombosis. 2007 Feb 1 3
65 17361128 Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. 2007 May 2
66 17659194 Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial. 2007 Jul 24 1
67 17697139 Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects. 2007 Oct 1
68 18004210 Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. 2007 Dec 1
69 16503718 Combination of clopidogrel and statins: a hypothetical interaction or therapeutic dilemma? 2006 Mar 1
70 16611111 Thienopyridines and statins: assessing a potential drug-drug interaction. 2006 3
71 16645157 Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. 2006 Aug 5
72 16754899 Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. 2006 Jun 6 3
73 16875906 A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention. 2006 Aug 2
74 17008981 Possible mechanisms of drug-induced aspirin and clopidogrel resistance. 2006 Oct 2
75 15604326 Lack of clopidogrel-CYP3A4 statin interaction in patients with acute coronary syndrome. 2005 Jan 4
76 15679472 Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence. 2005 Feb 2
77 16113837 The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease. 2005 Aug 1
78 16264203 Myonecrosis after elective percutaneous coronary intervention: effect of clopidogrel-statin interaction. 2005 Nov 1
79 14707025 Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. 2004 Jan 20 7
80 12485953 The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. 2003 Jan 9
81 12515739 Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. 2003 Jan 7 2
82 12925453 Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. 2003 Aug 26 4
83 14522569 Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study. 2003 Oct 1