Lidocaine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







28 Article(s)
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1 29263648 Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro. 2017 7
2 23530020 Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation. 2013 Jun 2
3 18679666 Pharmacokinetics of lidocaine and its metabolite in peridural anesthesia administered to pregnant women with gestational diabetes mellitus. 2008 Dec 1
4 18846481 Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. 2008 Nov 1
5 16894333 Lidocaine pharmacokinetics in postmenopausal women on hormone therapy. 2006 Sep-Oct 1
6 16918719 Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine. 2006 Aug 5
7 15845683 The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine. 2005 May 4
8 16435566 The effects of gender and menopause on serum lidocaine levels in smokers. 2005 Oct-Dec 1
9 14715049 Pharmacokinetics of local anaesthetics in infants and children. 2004 1
10 15383492 Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. 2004 Dec 1
11 15447735 Effect of itraconazole on the pharmacokinetics of inhaled lidocaine. 2004 Sep 3
12 12534644 Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. 2003 Jan 1
13 12708606 The effect of propofol (anesthetic and inhibitor of CYP3A4) on serum lidocaine concentrations in smokers and chronic alcohol consumers. 2003 Apr 1
14 12483453 Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus. 2002 Dec 1
15 10786743 The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro. 2000 May 1
16 10901707 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. 2000 Aug 1
17 10193676 Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine. 1999 Mar 4
18 10608481 Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. 1999 Nov 4
19 9832299 Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine. 1998 Sep 1
20 9862241 The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans. 1998 Dec 2
21 9143866 Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. 1997 2
22 9298257 Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin. 1997 Jul 1
23 8891878 Interaction between amiodarone and lidocaine. 1996 Oct 1
24 8953808 Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man. 1996 Jul-Aug 1
25 7636727 Rifampicin induction of lidocaine metabolism in cultured human hepatocytes. 1995 Aug 1
26 7756103 CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. 1995 Jan 2
27 8033500 Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men. 1994 Jul 1
28 1642641 Effect of age and gender on the activity of human hepatic CYP3A. 1992 Jul 22 1