Paclitaxel

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







68 Article(s)
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51 16144941 Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. 2005 Sep 1 1
52 16299241 Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. 2005 Nov 15 2
53 15175893 Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes. 2004 Sep 8
54 15304522 Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro. 2004 Dec 2
55 14512701 Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters. 2003 Nov 5
56 14522368 The role of chemotherapy in brain metastases. 2003 Oct 1
57 11901098 Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship. 2002 Apr 1
58 11914905 Effects of paclitaxel, cyclophosphamide, ifosfamide, tamoxifen and cyclosporine on the metabolism of methoxymorpholinodoxorubicin in human liver microsomes. 2002 Apr 1
59 12064370 Drug interaction studies between paclitaxel (Taxol) and OC144-093--a new modulator of MDR in cancer chemotherapy. 2002 Apr-Jun 1
60 12237780 Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. 2002 Sep 9 1
61 10421615 The use of human hepatocyte cultures to study the induction of cytochrome P-450. 1999 Aug 7
62 9492385 Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4. 1998 Mar 3
63 9675018 Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes. 1998 Jul 15 10
64 8791772 Assays of CYP2C8- and CYP3A4-mediated metabolism of taxol in vivo and in vitro. 1996 1
65 7473140 Variability in human cytochrome P450 paclitaxel metabolism. 1995 Nov 1
66 8703657 The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. 1995 Dec 1
67 7834963 Clinical pharmacokinetics of paclitaxel. 1994 Oct 1
68 7913410 Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. 1994 Aug 1 1