Cyclophosphamide

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







23 Article(s)
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1 32496149 Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors. 2021 Apr 2
2 30320358 Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. 2019 Jan 1
3 30500380 Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4. 2019 Jan 15 3
4 27206429 Monocrotophos Induces the Expression of Xenobiotic Metabolizing Cytochrome P450s (CYP2C8 and CYP3A4) and Neurotoxicity in Human Brain Cells. 2017 Jul 3
5 28976264 Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients. 2017 Oct 3
6 25860621 Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes. 2015 May 18 1
7 24768782 Significant role of CYP450 genetic variants in cyclophosphamide based breast cancer treatment outcomes: a multi-analytical strategy. 2014 Jul 1 1
8 22245954 The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients. 2012 May 1
9 21487929 The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes. 2011 Aug 1
10 20040700 Raltegravir-based HAART regimen in a patient with large B-cell lymphoma. 2010 Feb 1
11 18496131 Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. 2008 Jun 1
12 16595573 Hepatic veno-occlusive disease associated with immunosuppressive cyclophosphamide dosing and roxithromycin. 2006 Apr 1
13 17164692 Mechanisms of venoocclusive disease resulting from the combination of cyclophosphamide and roxithromycin. 2006 Dec 2
14 15656694 Interactions between antiretrovirals and antineoplastic drug therapy. 2005 1
15 15919850 Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. 2005 Sep 2
16 16087946 Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer. 2005 Sep 1 2
17 12065440 The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. 2002 Jul 10
18 11770832 Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes. 2001 Dec 1
19 10692561 Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. 2000 Apr 15 4
20 10322772 [Establishment of transgenic cell line CHL-3A4 and its metabolic activation]. 1998 Sep 1
21 9157990 Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. 1997 May 15 3
22 9331082 Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes. 1997 Oct 1 1
23 8242617 Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. 1993 Dec 1 1