| 101 |
17459328 | Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4. | 2007 Jul 1 |
2 |
| 102 |
17526062 | CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. | 2007 Jul 9 |
2 |
| 103 |
17555301 | Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. | 2007 Jul 3 |
2 |
| 104 |
17650504 | The one-electron autoxidation of human cytochrome P450 3A4. | 2007 Sep 14 |
3 |
| 105 |
17914095 | Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer. | 2007 Sep |
3 |
| 106 |
16337070 | Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5. | 2006 Feb 1 |
2 |
| 107 |
16414488 | Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men. | 2006 Jan-Feb |
1 |
| 108 |
16416302 | Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. | 2006 Mar |
2 |
| 109 |
16434211 | Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro. | 2006 Jun |
4 |
| 110 |
16443667 | Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). | 2006 Apr |
1 |
| 111 |
16481174 | Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. | 2006 Jun 1 |
1 |
| 112 |
16501008 | Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. | 2006 May |
1 |
| 113 |
16713641 | Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations. | 2006 Jun 30 |
1 |
| 114 |
16719384 | Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation. | 2006 |
2 |
| 115 |
16762915 | The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics. | 2006 Aug 18 |
1 |
| 116 |
16771648 | Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds. | 2006 May |
1 |
| 117 |
16941956 | Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs. | 2006 Aug |
1 |
| 118 |
17084830 | Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. | 2006 Dec 15 |
1 |
| 119 |
27699667 | Thin-Layer Chromatography Analysis of Human CYP3A-Catalyzed Testosterone 6β-Hydroxylation. | 2006 |
2 |
| 120 |
15546903 | CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. | 2005 Feb |
2 |
| 121 |
15608130 | Development and validation of a high-throughput radiometric CYP3A4/5 inhibition assay using tritiated testosterone. | 2005 Mar |
3 |
| 122 |
15667229 | The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria. | 2005 Feb 1 |
2 |
| 123 |
15684493 | Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. | 2005 Feb |
1 |
| 124 |
15689501 | Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. | 2005 May |
1 |
| 125 |
15845858 | Variability of CYP3A7 expression in human fetal liver. | 2005 Aug |
1 |
| 126 |
15910734 | Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. | 2005 Jun 1 |
1 |
| 127 |
16012074 | Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist. | 2005 May |
1 |
| 128 |
16112913 | Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. | 2005 Aug |
1 |
| 129 |
16601787 | Comparison of "high throughput" micromethods for determination of cytochrome P450 activities with classical methods using HPLC for product identification. | 2005 Dec |
1 |
| 130 |
14560315 | Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2. | 2004 Apr |
1 |
| 131 |
14634046 | Effect of age on in vitro triazolam biotransformation in male human liver microsomes. | 2004 Mar |
1 |
| 132 |
14709627 | Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. | 2004 Jan |
1 |
| 133 |
14712470 | Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. | 2004 Feb |
3 |
| 134 |
14977870 | Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. | 2004 Mar |
1 |
| 135 |
15232676 | Limited contribution of CYP3A5 to the hepatic 6beta-hydroxylation of testosterone. | 2004 Jul |
2 |
| 136 |
15277015 | Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions. | 2004 Jun |
1 |
| 137 |
15285839 | Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes. | 2004 Aug |
1 |
| 138 |
15369821 | Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment. | 2004 Oct 15 |
2 |
| 139 |
15373842 | Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4. | 2004 Oct |
2 |
| 140 |
15375599 | Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor. | 2004 Oct |
2 |
| 141 |
15459178 | Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status. | 2004 Dec 1 |
1 |
| 142 |
15540736 | CYP3A4 genetic variant and disease-free survival among white and black men after radical prostatectomy. | 2004 Nov |
2 |
| 143 |
15548719 | CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. | 2004 Nov 15 |
3 |
| 144 |
15560889 | In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol. | 2004 Dec 7 |
1 |
| 145 |
15621665 | P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification. | 2004 |
1 |
| 146 |
20945304 | Human cytochrome P450: metabolism of testosterone by CYP3A4 and inhibition by ketoconazole. | 2004 Jun |
1 |
| 147 |
12601364 | CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. | 2003 Mar |
1 |
| 148 |
12642463 | Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals. | 2003 Apr |
1 |
| 149 |
12692107 | The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. | 2003 Apr |
1 |
| 150 |
12766253 | Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. | 2003 Sep |
1 |