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24749245 | [Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes b5]. | 2014 Jan-Feb |
1 |
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24788541 | Up-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-AD. | 2014 |
2 |
| 53 |
24924803 | The PXR rs7643645 polymorphism is associated with the risk of higher prostate-specific antigen levels in prostate cancer patients. | 2014 |
1 |
| 54 |
25189890 | Efficient utilization of licorice root by alkaline extraction. | 2014 Sep-Oct |
1 |
| 55 |
25343516 | Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells. | 2014 |
2 |
| 56 |
23665933 | CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. | 2013 |
3 |
| 57 |
24027778 | Human cytochrome P450 3A4 and a carbon nanofiber modified film electrode as a platform for the simple evaluation of drug metabolism and inhibition reactions. | 2013 Nov 7 |
1 |
| 58 |
21842479 | Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. | 2012 Mar |
1 |
| 59 |
22298448 | Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo. | 2012 |
1 |
| 60 |
22305191 | Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes. | 2012 Mar 15 |
1 |
| 61 |
22326629 | Expression of active human P450 3A4 on the cell surface of Escherichia coli by Autodisplay. | 2012 Oct 15 |
1 |
| 62 |
22351667 | Comparative study of biological activity of three commercial products of Sasa senanensis Rehder leaf extract. | 2012 Mar-Apr |
2 |
| 63 |
22523293 | Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract. | 2012 May-Jun |
2 |
| 64 |
22719896 | Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6. | 2012 |
1 |
| 65 |
22939842 | Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor. | 2012 Nov 25 |
1 |
| 66 |
19921206 | Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample. | 2011 Apr |
1 |
| 67 |
21177853 | Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone. | 2011 Feb 18 |
5 |
| 68 |
21207936 | Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450. | 2011 Feb 9 |
2 |
| 69 |
21372830 | Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib. | 2011 Mar |
2 |
| 70 |
21722087 | Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. | 2011 Aug |
1 |
| 71 |
22001672 | Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro. | 2011 Dec |
1 |
| 72 |
22001938 | Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization. | 2011 Dec |
1 |
| 73 |
20203109 | Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. | 2010 Jun |
2 |
| 74 |
20233841 | CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells. | 2010 Jun |
3 |
| 75 |
20624855 | Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. | 2010 Oct |
1 |
| 76 |
20697309 | Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. | 2010 Oct |
1 |
| 77 |
20699409 | A 96-well plate assay for CYP4503A induction using cryopreserved human hepatocytes. | 2010 Nov |
1 |
| 78 |
20818746 | Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application. | 2010 Sep |
1 |
| 79 |
20879989 | Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4. | 2010 Dec 15 |
3 |
| 80 |
20937004 | In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. | 2010 Nov |
1 |
| 81 |
20977456 | Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes. | 2010 Nov |
1 |
| 82 |
19020497 | The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density. | 2009 Mar |
1 |
| 83 |
19414624 | Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer. | 2009 Aug |
1 |
| 84 |
19480428 | Quantum tunneling in testosterone 6beta-hydroxylation by cytochrome P450: reaction dynamics calculations employing multiconfiguration molecular-mechanical potential energy surfaces. | 2009 Oct 29 |
1 |
| 85 |
19490052 | Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy. | 2009 Aug |
1 |
| 86 |
17826359 | Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model. | 2008 Jan |
1 |
| 87 |
18322939 | Metabolic interactions of agrochemicals in humans. | 2008 Jun |
1 |
| 88 |
18328680 | Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. | 2008 Apr 23 |
1 |
| 89 |
18380401 | Drug interaction potentials among different brands of grapefruit juice. | 2008 Feb |
1 |
| 90 |
18395506 | Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4. | 2008 Jun 1 |
1 |
| 91 |
18431572 | Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. | 2008 Sep |
1 |
| 92 |
18647599 | Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers. | 2008 Sep 1 |
1 |
| 93 |
18803184 | Kinetic study of cytochrome P450 by capillary electrophoretically mediated microanalysis. | 2008 Sep |
2 |
| 94 |
18819885 | [Effect of ketoconazole on the activity of CYP4503A4 and CYP450 1A2 of hepatic microsomes in healthy adults]. | 2008 Aug |
1 |
| 95 |
19326769 | Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET). | 2008 |
1 |
| 96 |
21218106 | Experimental approaches to evaluate activities of cytochromes P450 3A. | 2008 Sep |
2 |
| 97 |
17213193 | Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation. | 2007 Mar 9 |
1 |
| 98 |
17357170 | Fluorescent probes for rapid screening of potential drug-drug interactions at the CYP3A4 level. | 2007 May |
1 |
| 99 |
17368239 | Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity. | 2007 Mar |
1 |
| 100 |
17392390 | Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. | 2007 Jul |
1 |