| 1 |
33384383 | Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1'-Hydroxylation and Testosterone 6β-Hydroxylation. | 2021 Mar |
5 |
| 2 |
33790108 | Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies. | 2021 |
1 |
| 3 |
33826998 | Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants. | 2021 Jun |
3 |
| 4 |
33933755 | Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4. | 2021 Aug 5 |
1 |
| 5 |
34196520 | Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase. | 2021 Jul 20 |
1 |
| 6 |
34326139 | Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4. | 2021 Sep |
2 |
| 7 |
34473615 | In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity. | 2021 |
1 |
| 8 |
32001245 | Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies. | 2020 Mar 30 |
5 |
| 9 |
32049373 | Mechanistic Insights into the Regio- and Stereoselectivities of Testosterone and Dihydrotestosterone Hydroxylation Catalyzed by CYP3A4 and CYP19A1. | 2020 May 15 |
6 |
| 10 |
32682830 | Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure. | 2020 Nov 1 |
1 |
| 11 |
33105851 | Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes. | 2020 Oct 22 |
1 |
| 12 |
29320899 | In vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A. | 2019 Jan |
1 |
| 13 |
30488748 | Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor. | 2019 Oct |
1 |
| 14 |
30517006 | CYP3A4/5 Activity Probed with Testosterone and Midazolam: Correlation between Two Substrates at the Microsomal and Enzyme Levels. | 2019 Jan 7 |
2 |
| 15 |
31108125 | In silico and in vitro analysis of genetic variants of the equine CYP3A94, CYP3A95 and CYP3A97 isoenzymes. | 2019 Oct |
2 |
| 16 |
31301485 | A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes. | 2019 Sep 1 |
1 |
| 17 |
31339834 | Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5. | 2019 |
5 |
| 18 |
31755290 | beta-caryophyllene oxide and trans-nerolidol affect enzyme activity of CYP3A4 - in vitro and in silico studies. | 2019 Nov 22 |
2 |
| 19 |
29155491 | Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. | 2018 Apr |
1 |
| 20 |
29382727 | Membrane-embedded substrate recognition by cytochrome P450 3A4. | 2018 Mar 16 |
1 |
| 21 |
29719052 | Effect of single-walled carbon nanotubes on cytochrome P450 activity in human liver microsomes in vitro. | 2018 May |
1 |
| 22 |
29958895 | Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency. | 2018 Sep 1 |
2 |
| 23 |
30125880 | Polydopamine functionalized nanoporous graphene foam as nanoreactor for efficient electrode-driven metabolism of steroid hormones. | 2018 Nov 15 |
2 |
| 24 |
30301254 | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 Oct 7 |
1 |
| 25 |
27794450 | 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism. | 2017 Feb |
1 |
| 26 |
27934636 | Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor. | 2017 Feb |
1 |
| 27 |
28238727 | Testosterone metabolism of equine single CYPs of the 3A subfamily compared to the human CYP3A4. | 2017 Jun |
1 |
| 28 |
28344076 | Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. | 2017 Jun |
1 |
| 29 |
28944677 | Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS. | 2017 Nov 3 |
1 |
| 30 |
28986474 | Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7. | 2017 Dec |
10 |
| 31 |
26490246 | Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone. | 2016 Jan |
1 |
| 32 |
26774838 | The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4. | 2016 May |
2 |
| 33 |
26899743 | Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4. | 2016 Feb 22 |
1 |
| 34 |
27110874 | Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes. | 2016 Aug |
1 |
| 35 |
27323294 | Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail. | 2016 Sep |
3 |
| 36 |
25145883 | Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes. | 2015 Feb |
1 |
| 37 |
25322914 | Time-dependent inhibition of CYP3A4 by gallic acid in human liver microsomes and recombinant systems. | 2015 Mar |
1 |
| 38 |
25457200 | Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. | 2015 Mar |
1 |
| 39 |
25619394 | Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells. | 2015 Feb |
1 |
| 40 |
25640685 | Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs. | 2015 Jun |
1 |
| 41 |
25678418 | Regioselective hydroxylation of steroid hormones by human cytochromes P450. | 2015 May |
1 |
| 42 |
25727956 | Interaction of rocuronium with human liver cytochromes P450. | 2015 Feb |
1 |
| 43 |
25892190 | Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig. | 2015 Nov |
1 |
| 44 |
26070839 | Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes. | 2015 Sep |
1 |
| 45 |
26223917 | Single nucleotide polymorphism of CYP3A4 intron 2 and its influence on CYP3A4 mRNA expression and liver enzymatic activity in human liver. | 2015 Aug |
1 |
| 46 |
26296860 | In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib. | 2015 Dec 1 |
1 |
| 47 |
26350737 | [Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes b5]. | 2015 Jul-Aug |
1 |
| 48 |
26409144 | Comprehensive assessment of Cytochrome P450 reactions: A multiplex approach using real-time ESI-MS. | 2015 Dec |
1 |
| 49 |
27022466 | miRNA-27b levels are associated with CYP3A activity in vitro and in vivo. | 2015 Dec |
1 |
| 50 |
24242708 | Vitamin D receptor agonist EB1089 is a potent regulator of prostatic "intracrine" metabolism. | 2014 Feb |
1 |