51 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 34903590 | Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping. | 2022 Mar | 1 |
2 | 35570332 | Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. | 2022 May 15 | 1 |
3 | 30219715 | Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants. | 2018 Oct | 1 |
4 | 28340451 | The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide. | 2017 Apr | 1 |
5 | 25434721 | Overexpression of CYP3A5 attenuates inducibility and activity of CYP3A4 in HepG2 cells. | 2015 Apr | 1 |
6 | 24027778 | Human cytochrome P450 3A4 and a carbon nanofiber modified film electrode as a platform for the simple evaluation of drug metabolism and inhibition reactions. | 2013 Nov 7 | 1 |
7 | 24166670 | Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? | 2013 | 4 |
8 | 21842479 | Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. | 2012 Mar | 1 |
9 | 22266842 | Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. | 2012 Apr | 1 |
10 | 22480862 | Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. | 2012 Aug | 1 |
11 | 21716273 | Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study. | 2011 Aug | 1 |
12 | 21832258 | Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. | 2011 Sep | 1 |
13 | 20924570 | Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women. | 2010 Dec | 2 |
14 | 18950609 | Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. | 2009 Apr 15 | 1 |
15 | 19444798 | A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. | 2009 Nov | 1 |
16 | 19451401 | Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. | 2009 Aug | 1 |
17 | 17346248 | A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. | 2007 Mar | 1 |
18 | 17374625 | Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? | 2007 Apr | 1 |
19 | 16595712 | Expression, purification, and characterization of mouse CYP2d22. | 2006 Jul | 1 |
20 | 15784650 | CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. | 2005 Jul | 1 |
21 | 15370963 | Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4. | 2004 May | 4 |
22 | 12781333 | An amperometric biosensor with human CYP3A4 as a novel drug screening tool. | 2003 Jun 1 | 1 |
23 | 12871048 | The metabolism of diclofenac--enzymology and toxicology perspectives. | 2003 Aug | 2 |
24 | 12893521 | In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes. | 2003 Jul | 2 |
25 | 14652237 | Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. | 2003 Dec 3 | 1 |
26 | 11816004 | Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection. | 2002 Feb | 2 |
27 | 12228192 | Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine. | 2002 Oct | 2 |
28 | 12433827 | Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. | 2002 Dec | 1 |
29 | 11353757 | In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin. | 2001 Jun | 5 |
30 | 11377054 | A direct injection capillary electrophoretic technique for miniaturized high-throughput metabolic screening of the CYP 3A4 enzyme using quinidine as a probe. | 2001 Jul | 2 |
31 | 11408374 | Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. | 2001 Jul | 1 |
32 | 10677595 | Cytochrome P-450 activities in human and rat brain microsomes. | 2000 Feb 14 | 1 |
33 | 10821163 | Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. | 2000 Apr | 1 |
34 | 10950847 | Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. | 2000 Sep | 1 |
35 | 10950860 | Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. | 2000 Sep | 1 |
36 | 10976551 | Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6. | 2000 Aug | 3 |
37 | 11501186 | In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. | 2000 Aug | 1 |
38 | 9929520 | Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine. | 1999 Feb | 1 |
39 | 10086984 | In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. | 1999 Apr | 3 |
40 | 10381752 | Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. | 1999 Jul | 5 |
41 | 10418968 | Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. | 1999 Jun 1 | 1 |
42 | 10484078 | Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. | 1999 Oct 1 | 1 |
43 | 8960070 | Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. | 1997 Jan 10 | 1 |
44 | 9105395 | Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4. | 1997 Feb 21 | 2 |
45 | 9143866 | Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. | 1997 | 2 |
46 | 9390107 | Itraconazole increases plasma concentrations of quinidine. | 1997 Nov | 5 |
47 | 9431831 | Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. | 1997 Dec | 1 |
48 | 8548776 | Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. | 1996 Jan 1 | 1 |
49 | 8820421 | Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. | 1996 Mar | 2 |
50 | 1642641 | Effect of age and gender on the activity of human hepatic CYP3A. | 1992 Jul 22 | 1 |