Quinidine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







51 Article(s)
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1 34903590 Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping. 2022 Mar 1
2 35570332 Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. 2022 May 15 1
3 30219715 Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants. 2018 Oct 1
4 28340451 The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide. 2017 Apr 1
5 25434721 Overexpression of CYP3A5 attenuates inducibility and activity of CYP3A4 in HepG2 cells. 2015 Apr 1
6 24027778 Human cytochrome P450 3A4 and a carbon nanofiber modified film electrode as a platform for the simple evaluation of drug metabolism and inhibition reactions. 2013 Nov 7 1
7 24166670 Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? 2013 4
8 21842479 Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. 2012 Mar 1
9 22266842 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. 2012 Apr 1
10 22480862 Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. 2012 Aug 1
11 21716273 Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study. 2011 Aug 1
12 21832258 Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. 2011 Sep 1
13 20924570 Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women. 2010 Dec 2
14 18950609 Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. 2009 Apr 15 1
15 19444798 A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. 2009 Nov 1
16 19451401 Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. 2009 Aug 1
17 17346248 A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. 2007 Mar 1
18 17374625 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? 2007 Apr 1
19 16595712 Expression, purification, and characterization of mouse CYP2d22. 2006 Jul 1
20 15784650 CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. 2005 Jul 1
21 15370963 Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4. 2004 May 4
22 12781333 An amperometric biosensor with human CYP3A4 as a novel drug screening tool. 2003 Jun 1 1
23 12871048 The metabolism of diclofenac--enzymology and toxicology perspectives. 2003 Aug 2
24 12893521 In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes. 2003 Jul 2
25 14652237 Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. 2003 Dec 3 1
26 11816004 Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection. 2002 Feb 2
27 12228192 Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine. 2002 Oct 2
28 12433827 Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. 2002 Dec 1
29 11353757 In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin. 2001 Jun 5
30 11377054 A direct injection capillary electrophoretic technique for miniaturized high-throughput metabolic screening of the CYP 3A4 enzyme using quinidine as a probe. 2001 Jul 2
31 11408374 Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. 2001 Jul 1
32 10677595 Cytochrome P-450 activities in human and rat brain microsomes. 2000 Feb 14 1
33 10821163 Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. 2000 Apr 1
34 10950847 Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. 2000 Sep 1
35 10950860 Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. 2000 Sep 1
36 10976551 Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6. 2000 Aug 3
37 11501186 In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. 2000 Aug 1
38 9929520 Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine. 1999 Feb 1
39 10086984 In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. 1999 Apr 3
40 10381752 Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. 1999 Jul 5
41 10418968 Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. 1999 Jun 1 1
42 10484078 Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. 1999 Oct 1 1
43 8960070 Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. 1997 Jan 10 1
44 9105395 Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4. 1997 Feb 21 2
45 9143866 Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. 1997 2
46 9390107 Itraconazole increases plasma concentrations of quinidine. 1997 Nov 5
47 9431831 Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. 1997 Dec 1
48 8548776 Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. 1996 Jan 1 1
49 8820421 Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. 1996 Mar 2
50 1642641 Effect of age and gender on the activity of human hepatic CYP3A. 1992 Jul 22 1