| 1 |
34903590 | Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping. | 2022 Mar |
1 |
| 2 |
35570332 | Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. | 2022 May 15 |
1 |
| 3 |
30219715 | Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants. | 2018 Oct |
1 |
| 4 |
28340451 | The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide. | 2017 Apr |
1 |
| 5 |
25434721 | Overexpression of CYP3A5 attenuates inducibility and activity of CYP3A4 in HepG2 cells. | 2015 Apr |
1 |
| 6 |
24027778 | Human cytochrome P450 3A4 and a carbon nanofiber modified film electrode as a platform for the simple evaluation of drug metabolism and inhibition reactions. | 2013 Nov 7 |
1 |
| 7 |
24166670 | Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? | 2013 |
4 |
| 8 |
21842479 | Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. | 2012 Mar |
1 |
| 9 |
22266842 | Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. | 2012 Apr |
1 |
| 10 |
22480862 | Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. | 2012 Aug |
1 |
| 11 |
21716273 | Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study. | 2011 Aug |
1 |
| 12 |
21832258 | Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. | 2011 Sep |
1 |
| 13 |
20924570 | Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women. | 2010 Dec |
2 |
| 14 |
18950609 | Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. | 2009 Apr 15 |
1 |
| 15 |
19444798 | A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. | 2009 Nov |
1 |
| 16 |
19451401 | Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. | 2009 Aug |
1 |
| 17 |
17346248 | A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. | 2007 Mar |
1 |
| 18 |
17374625 | Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? | 2007 Apr |
1 |
| 19 |
16595712 | Expression, purification, and characterization of mouse CYP2d22. | 2006 Jul |
1 |
| 20 |
15784650 | CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. | 2005 Jul |
1 |
| 21 |
15370963 | Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4. | 2004 May |
4 |
| 22 |
12781333 | An amperometric biosensor with human CYP3A4 as a novel drug screening tool. | 2003 Jun 1 |
1 |
| 23 |
12871048 | The metabolism of diclofenac--enzymology and toxicology perspectives. | 2003 Aug |
2 |
| 24 |
12893521 | In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes. | 2003 Jul |
2 |
| 25 |
14652237 | Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. | 2003 Dec 3 |
1 |
| 26 |
11816004 | Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection. | 2002 Feb |
2 |
| 27 |
12228192 | Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine. | 2002 Oct |
2 |
| 28 |
12433827 | Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. | 2002 Dec |
1 |
| 29 |
11353757 | In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin. | 2001 Jun |
5 |
| 30 |
11377054 | A direct injection capillary electrophoretic technique for miniaturized high-throughput metabolic screening of the CYP 3A4 enzyme using quinidine as a probe. | 2001 Jul |
2 |
| 31 |
11408374 | Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. | 2001 Jul |
1 |
| 32 |
10677595 | Cytochrome P-450 activities in human and rat brain microsomes. | 2000 Feb 14 |
1 |
| 33 |
10821163 | Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. | 2000 Apr |
1 |
| 34 |
10950847 | Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. | 2000 Sep |
1 |
| 35 |
10950860 | Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. | 2000 Sep |
1 |
| 36 |
10976551 | Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6. | 2000 Aug |
3 |
| 37 |
11501186 | In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. | 2000 Aug |
1 |
| 38 |
9929520 | Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine. | 1999 Feb |
1 |
| 39 |
10086984 | In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. | 1999 Apr |
3 |
| 40 |
10381752 | Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. | 1999 Jul |
5 |
| 41 |
10418968 | Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. | 1999 Jun 1 |
1 |
| 42 |
10484078 | Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. | 1999 Oct 1 |
1 |
| 43 |
8960070 | Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. | 1997 Jan 10 |
1 |
| 44 |
9105395 | Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4. | 1997 Feb 21 |
2 |
| 45 |
9143866 | Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. | 1997 |
2 |
| 46 |
9390107 | Itraconazole increases plasma concentrations of quinidine. | 1997 Nov |
5 |
| 47 |
9431831 | Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. | 1997 Dec |
1 |
| 48 |
8548776 | Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. | 1996 Jan 1 |
1 |
| 49 |
8820421 | Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. | 1996 Mar |
2 |
| 50 |
1642641 | Effect of age and gender on the activity of human hepatic CYP3A. | 1992 Jul 22 |
1 |