Furocoumarins

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cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







28 Article(s)
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1 32664320 The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies. 2020 Jul 10 2
2 31480231 Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6',7'-Dihydroxybergamottin. 2019 Aug 30 1
3 30218442 Increased tacrolimus blood concentration by Beni-Madonna - a new hybrid citrus cultivar categorized as 'Tangor', in a liver transplant patient: likely furanocoumarin-mediated inhibition of CYP3A4 or P-glycoprotein. 2018 Dec 1
4 28966261 Synthesis of Furanocoumarin, Benzofuran and Coumarin Derivatives Possessing an Inhibitory Effect on Human CYP, and Elucidation of the Inhibitory Mechanism. 2017 5
5 25008344 Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation. 2014 Oct 1
6 23257392 Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin. 2013 1
7 22083560 Established HPLC fraction analysis to predict furanocoumarin-based herb-drug metabolic interactions. 2012 Jun 2
8 22155270 Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity. 2012 Mar 1
9 23146034 Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. 2012 Dec 2
10 19689106 Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4. 2009 Sep 1
11 18183388 Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4. 2008 Feb 1
12 18189136 Binding of furanocoumarins in grapefruit juice to Aspergillus niger hyphae. 2008 Mar 4
13 18380401 Drug interaction potentials among different brands of grapefruit juice. 2008 Feb 2
14 19012403 Removal of furanocoumarins in grapefruit juice by edible fungi. 2008 Dec 24 2
15 17827777 Synthetic models related to furanocoumarin-CYP 3A4 interactions. comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 activity. 2007 Sep 5
16 17995595 Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins. 2007 Oct 2
17 16299162 Development of novel furanocoumarin dimers as potent and selective inhibitors of CYP3A4. 2006 Feb 3
18 16338240 Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes. 2006 Apr 15 1
19 16481174 Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. 2006 Jun 1 2
20 16604230 Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4. 2006 Apr 21 2
21 16809802 Drug-drug interaction after single oral doses of the furanocoumarin methoxsalen and cyclosporine. 2006 Jul 1
22 15269184 Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties. 2004 Oct 1
23 11388644 Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions. 2001 Apr 1
24 11737987 Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. 2001 Sep-Dec 4
25 10859150 Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. 2000 Jul 4
26 10877530 Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity. 2000 Feb 6
27 10903978 Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. 2000 Jul 1
28 9351897 Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. 1997 Nov 2