| 51 |
10926350 | Drug interactions with cisapride: clinical implications. | 2000 Jul |
1 |
| 52 |
11038155 | CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes. | 2000 Nov |
1 |
| 53 |
11125847 | Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. | 2000 Nov 10 |
4 |
| 54 |
11501186 | In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. | 2000 Aug |
1 |
| 55 |
20575842 | Certain clinically-utilized antibiotics enhance the behavioural effects of cocaine. | 2000 Jul 1 |
2 |
| 56 |
9929520 | Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine. | 1999 Feb |
1 |
| 57 |
9931427 | Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes. | 1999 Jan 29 |
1 |
| 58 |
10216279 | 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. | 1999 Apr 19 |
1 |
| 59 |
10233205 | Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4. | 1999 Apr |
1 |
| 60 |
10359460 | Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. | 1999 Apr 1 |
1 |
| 61 |
10411567 | Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. | 1999 Aug |
1 |
| 62 |
10417492 | Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. | 1999 Aug |
1 |
| 63 |
10454485 | Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. | 1999 Sep |
1 |
| 64 |
10484078 | Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. | 1999 Oct 1 |
1 |
| 65 |
10548453 | Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily. | 1999 Sep |
1 |
| 66 |
10570031 | Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. | 1999 Dec |
2 |
| 67 |
10647912 | Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent. | 1999 Dec |
2 |
| 68 |
9523995 | CYP3A4-mediated oxidation of lisofylline to lisofylline 4,5-diol in human liver microsomes. | 1998 Mar |
1 |
| 69 |
9600717 | Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. | 1998 Mar |
1 |
| 70 |
9604298 | Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms. | 1998 Apr |
1 |
| 71 |
9618413 | Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. | 1998 Jun |
2 |
| 72 |
9681669 | Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation. | 1998 May |
2 |
| 73 |
9698291 | Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes. | 1998 Aug |
1 |
| 74 |
9806945 | Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. | 1998 Nov |
4 |
| 75 |
9825830 | In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. | 1998 Oct |
2 |
| 76 |
9845092 | Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. | 1998 Nov 1 |
4 |
| 77 |
9884161 | Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. | 1998 Dec |
1 |
| 78 |
8960070 | Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. | 1997 Jan 10 |
1 |
| 79 |
9023313 | Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. | 1997 Feb |
1 |
| 80 |
9029057 | Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. | 1997 Feb |
2 |
| 81 |
9113345 | Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. | 1997 Apr |
1 |
| 82 |
9131945 | Cytochromes P450 mediating the N-demethylation of amitriptyline. | 1997 Feb |
1 |
| 83 |
9152594 | Metabolism of phencyclidine by human liver microsomes. | 1997 May |
1 |
| 84 |
9223567 | Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. | 1997 Jul |
1 |
| 85 |
9278210 | Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A. | 1997 Aug |
1 |
| 86 |
9321513 | Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. | 1997 Oct |
1 |
| 87 |
9394028 | In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. | 1997 Dec |
1 |
| 88 |
8548776 | Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. | 1996 Jan 1 |
1 |
| 89 |
8615885 | Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. | 1996 Jan 26 |
1 |
| 90 |
8627581 | Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. | 1996 May |
2 |
| 91 |
8712396 | Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. | 1996 Jan |
1 |
| 92 |
8765473 | Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. | 1996 Sep 13 |
2 |
| 93 |
8818573 | Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. | 1996 Jul |
1 |
| 94 |
8820421 | Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. | 1996 Mar |
2 |
| 95 |
8820426 | CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. | 1996 Mar |
2 |
| 96 |
8886604 | Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes. | 1996 Sep |
1 |
| 97 |
8968357 | Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. | 1996 Dec |
1 |
| 98 |
7503788 | Human liver oxidative metabolism of O6-benzylguanine. | 1995 Oct 26 |
1 |
| 99 |
7586950 | Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. | 1995 Nov |
1 |
| 100 |
7587944 | Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. | 1995 Jun |
3 |