Estradiol

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







22 Article(s)
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1 27995413 Is cytochrome P450 3A4 regulated by menstrual cycle hormones in control endometrium and endometriosis? 2017 Mar 2
2 25678418 Regioselective hydroxylation of steroid hormones by human cytochromes P450. 2015 May 1
3 22837389 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. 2013 Feb 1
4 23223499 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. 2013 Feb 1
5 20621111 Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study. 2010 Dec 1
6 17570247 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. 2007 Jul 2
7 17636047 Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. 2007 Oct 1
8 17936932 Human metabolic interactions of environmental chemicals. 2007 1
9 16713641 Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations. 2006 Jun 30 1
10 16790556 Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. 2006 Sep 1
11 15817670 Potential role for human cytochrome P450 3A4 in estradiol homeostasis. 2005 Jul 2
12 16112414 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. 2005 Sep 28 1
13 15050414 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. 2004 Apr 1 1
14 15116059 The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. 2004 May 1
15 12865317 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. 2003 Aug 1
16 14690416 Direct interaction between substrates and endogenous steroids in the active site may change the activity of cytochrome P450 3A4. 2003 Dec 30 1
17 12166560 Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide. 2002 Jul 1
18 11454902 Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5. 2001 Aug 1
19 11741520 Role of cytochrome P450 in estradiol metabolism in vitro. 2001 Feb 2
20 11067738 Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 reductase. 2000 Nov 15 1
21 9714305 Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms. 1998 Jun 1 1
22 9047321 Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. 1997 Feb 25 3