Carbamazepine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







146 Article(s)
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51 24292054 Prediction of in vivo carbamazepine 10,11-epoxidation from in vitro metabolic studies with human liver microsomes: importance of its sigmoidal kinetics. 2013 1
52 24382036 [Pulmonary embolism due to interaction between rivaroxaban and carbamazepine]. 2013 1
53 21996064 Histone deacetylase 1 is required for Carbamazepine-induced CYP3A4 expression. 2012 Jan 25 7
54 22197672 Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4. 2012 Jan 15 2
55 21190921 Therapeutic effects of ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers. 2011 Jan 2
56 21294720 Cellular localization and functional significance of CYP3A4 in the human epileptic brain. 2011 Mar 2
57 21441468 Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs. 2011 Jul 1
58 21832258 Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. 2011 Sep 1
59 21992114 The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. 2011 Dec 20 2
60 20369030 Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. 2010 Mar 1 1
61 20699409 A 96-well plate assay for CYP4503A induction using cryopreserved human hepatocytes. 2010 Nov 1
62 20847137 CYP3A4*16 and CYP3A4*18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs. 2010 Dec 4
63 19006545 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. 2009 Jan 1
64 19182847 Carbamazepine and falsely positive screening tests for Cushing's syndrome. 2009 Jan 23 1
65 19255940 Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine. 2009 Feb 1
66 19451401 Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. 2009 Aug 1
67 19744012 Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients. 2009 Oct 2
68 17971810 Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin. 2008 Jul 2
69 18096676 CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile. 2008 Mar 12
70 18279471 Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy. 2008 May 2
71 18372180 An epoxidation mechanism of carbamazepine by CYP3A4. 2008 May 1 5
72 18420779 Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications. 2008 Jul 1
73 18463198 Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. 2008 Aug 4
74 18781906 Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients. 2008 Sep 1
75 18783297 General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. 2008 2
76 17346248 A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. 2007 Mar 4
77 17374625 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? 2007 Apr 1
78 17502775 Pharmacokinetics of aripiprazole and concomitant carbamazepine. 2007 Jun 1
79 17541885 Effects of comedication on the serum levels of aripiprazole: evidence from a routine therapeutic drug monitoring service. 2007 May 1
80 18033049 [Carbamazepine and clarithromycin: a clinically relevant drug interaction]. 2007 Nov 1
81 16390352 Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. 2006 Jan 1
82 16600452 Effect of carbamazepine on the single oral dose pharmacokinetics of perospirone and its active metabolite. 2006 Sep 30 1
83 16720703 Carbamazepine toxicity induced by lopinavir/ritonavir and nelfinavir. 2006 Jun 1
84 17190925 Optimizing therapy of seizures in women who use oral contraceptives. 2006 Dec 26 1
85 15572649 Predictive models of CYP3A4 Heteroactivation: in vitro-in vivo scaling and pharmacophore modeling. 2005 Mar 2
86 15673597 Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. 2005 May 3
87 15708356 Novel pathways of bile acid metabolism involving CYP3A4. 2005 Feb 21 1
88 15747502 Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. 2005 1
89 15829439 Study of urinary 6 beta-hydroxycortisol/cortisol ratio in spot urine sample as a biomarker of 3A4 enzyme activity in healthy and epileptic subjects of Egyptian population. 2005 Jun 2
90 16135660 Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene. 2005 Dec 2
91 16318439 Clinical use of carbamazepine for bipolar disorders. 2005 Dec 1
92 15024831 [A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. 2004 Jan 1
93 15298747 Urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction. 2004 Jul 1
94 15371980 Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. 2004 Sep 1
95 15383492 Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. 2004 Dec 1
96 15519127 Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. 2004 Nov 2
97 12606595 In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine. 2003 Jun 8
98 12642469 CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. 2003 Apr 2
99 12673034 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. 2003 Apr 3
100 14512885 Sex is a major determinant of CYP3A4 expression in human liver. 2003 Oct 1