Epoxy Compounds

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







13 Article(s)
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1 35121040 Human cytochrome P450 3A-mediated two-step oxidation metabolism of dimethomorph: Implications in the mechanism-based enzyme inactivation. 2022 May 20 1
2 35139477 Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation. 2022 Apr 1
3 35512804 Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A. 2022 May 5 2
4 33436520 Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone. 2021 Apr 1
5 34326139 Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4. 2021 Sep 1
6 31485694 Metabolism of carcinogenic alpha-asarone by human cytochrome P450 enzymes. 2020 Feb 1
7 31833760 "Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4": Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping. 2020 Feb 17 2
8 32469513 Reply to Letter to Editor from Veeravalli and Dash on "Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4: Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping". 2020 Jul 20 1
9 30142320 The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. 2018 Oct 1
10 15572649 Predictive models of CYP3A4 Heteroactivation: in vitro-in vivo scaling and pharmacophore modeling. 2005 Mar 1
11 14672753 Herbal bioactivation: the good, the bad and the ugly. 2004 Jan 9 1
12 12397847 Pharmacokinetics of mood stabilizers and new anticonvulsants. 2002 Winter 1
13 8261428 Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1. 1994 Jan 1 1