| 451 |
10418968 | Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. | 1999 Jun 1 |
1 |
| 452 |
10447581 | Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide. | 1999 |
1 |
| 453 |
10456482 | Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions. | 1999 Jul |
2 |
| 454 |
10460808 | Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. | 1999 Sep |
1 |
| 455 |
10484078 | Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. | 1999 Oct 1 |
1 |
| 456 |
10525096 | Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. | 1999 Nov |
1 |
| 457 |
10546921 | Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. | 1999 Oct |
1 |
| 458 |
10570031 | Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. | 1999 Dec |
2 |
| 459 |
10574228 | Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. | 1999 |
1 |
| 460 |
10579473 | Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole. | 1999 Nov |
3 |
| 461 |
10583027 | Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity. | 1999 Oct |
1 |
| 462 |
10603245 | Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe. | 1999 Dec 15 |
1 |
| 463 |
10647912 | Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent. | 1999 Dec |
1 |
| 464 |
10952769 | Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. | 1999 May-Aug |
1 |
| 465 |
11741214 | Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. | 1999 |
2 |
| 466 |
9491822 | Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. | 1998 Feb |
1 |
| 467 |
9531525 | Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. | 1998 Apr |
1 |
| 468 |
9549641 | Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. | 1998 Feb |
1 |
| 469 |
9584328 | Cytochrome P450 specificity of metabolism and interactions of oxybutynin in human liver microsomes. | 1998 Apr |
1 |
| 470 |
9616194 | Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. | 1998 Jun |
2 |
| 471 |
9649346 | Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions. | 1998 Jul |
1 |
| 472 |
9698291 | Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes. | 1998 Aug |
1 |
| 473 |
9765359 | Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. | 1998 Oct |
2 |
| 474 |
9825830 | In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. | 1998 Oct |
2 |
| 475 |
9839763 | Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses. | 1998 Nov |
1 |
| 476 |
9855331 | Pharmacokinetic drug interactions of vinca alkaloids: summary of case reports. | 1998 Nov-Dec |
1 |
| 477 |
9868741 | Fluvoxamine is a potent inhibitor of the metabolism of caffeine in vitro. | 1998 Dec |
2 |
| 478 |
9023313 | Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. | 1997 Feb |
1 |
| 479 |
9029042 | Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases. | 1997 Feb |
1 |
| 480 |
9029057 | Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. | 1997 Feb |
2 |
| 481 |
9088587 | Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects. | 1997 Mar |
1 |
| 482 |
9113345 | Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. | 1997 Apr |
2 |
| 483 |
9131945 | Cytochromes P450 mediating the N-demethylation of amitriptyline. | 1997 Feb |
1 |
| 484 |
9152603 | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. | 1997 May |
1 |
| 485 |
9223567 | Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. | 1997 Jul |
1 |
| 486 |
9246018 | Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. | 1997 Jul |
2 |
| 487 |
9262358 | Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes. | 1997 Aug |
1 |
| 488 |
9353355 | Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. | 1997 Nov |
1 |
| 489 |
9357097 | Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy. | 1997 Oct |
1 |
| 490 |
9357389 | Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin. | 1997 Oct |
2 |
| 491 |
9384460 | The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. | 1997 Nov |
1 |
| 492 |
9408089 | Dexamethasone metabolism in vitro: species differences. | 1997 Jul |
1 |
| 493 |
9408807 | Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men. | 1997 Dec |
1 |
| 494 |
9431831 | Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. | 1997 Dec |
1 |
| 495 |
9566442 | In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin. | 1997 Dec |
1 |
| 496 |
8548776 | Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs. | 1996 Jan 1 |
1 |
| 497 |
8613906 | Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. | 1996 Apr |
1 |
| 498 |
8615885 | Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. | 1996 Jan 26 |
1 |
| 499 |
8627581 | Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. | 1996 May |
1 |
| 500 |
8627582 | Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability. | 1996 May |
2 |